Charles Laughton
Overview
Explore the profile of Charles Laughton including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
318
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Morgunova E, Nagy G, Yin Y, Zhu F, Nayak S, Xiao T, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39753777
Transcription factors (TFs) recognize specific bases within their DNA-binding motifs, with each base contributing nearly independently to total binding energy. However, the energetic contributions of particular dinucleotides can deviate strongly...
2.
Maddocks J, Dans P, Cheatham 3rd T, Harris S, Laughton C, Orozco M, et al.
Biophys Rev
. 2024 Aug;
16(3):259-262.
PMID: 39099838
This editorial for Volume 16, Issue 3 of highlights the three-dimensional structural and dynamic information encoded in DNA sequences and introduces the topics covered in this special issue of the...
3.
Styliari I, Taresco V, Theophilus A, Alexander C, Garnett M, Laughton C
RSC Adv
. 2022 May;
10(33):19521-19533.
PMID: 35515456
The formulation of drug compounds into nanoparticles has many potential advantages in enhancing bioavailability and improving therapeutic efficacy. However, few drug molecules will assemble into stable, well-defined nanoparticulate structures. Amphiphilic...
4.
da Rosa G, Grille L, Calzada V, Ahmad K, Arcon J, Battistini F, et al.
Biophys Rev
. 2022 Jan;
13(6):995-1005.
PMID: 35059023
The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was...
5.
de Albuquerque S, Cianni L, De Vita D, Duque C, Gomes A, Gomes P, et al.
Chem Biol Drug Des
. 2020 Oct;
96(3):948-960.
PMID: 33058457
Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations? This work describes the development of a random forests model...
6.
Meletiou A, Gebbie-Rayet J, Laughton C
J Chem Inf Model
. 2019 Jul;
59(8):3359-3364.
PMID: 31339723
The configuration of most current academic high-performance computing (HPC) resources tends to enforce ways of working with, and thinking about, molecular dynamics (MD) simulations that are not always optimal. For...
7.
Sutthibutpong T, Matek C, Benham C, Slade G, Noy A, Laughton C, et al.
Nucleic Acids Res
. 2016 Sep;
44(19):9121-9130.
PMID: 27664220
It is well established that gene regulation can be achieved through activator and repressor proteins that bind to DNA and switch particular genes on or off, and that complex metabolic...
8.
μABC: a systematic microsecond molecular dynamics study of tetranucleotide sequence effects in B-DNA
Pasi M, Maddocks J, Beveridge D, Bishop T, Case D, Cheatham 3rd T, et al.
Nucleic Acids Res
. 2014 Sep;
42(19):12272-83.
PMID: 25260586
We present the results of microsecond molecular dynamics simulations carried out by the ABC group of laboratories on a set of B-DNA oligomers containing the 136 distinct tetranucleotide base sequences....
9.
Garton M, Laughton C
J Mol Biol
. 2013 May;
425(16):2910-21.
PMID: 23702294
Eukaryotic chromosomes are capped by telomeres, nucleoprotein complexes that prevent chromosome end-to-end fusions and control cell ageing. Two proteins in this complex, telomere repeat binding factors (TRF1 and TRF2), specifically...
10.
Rannou O, Le Chatelier E, Larson M, Nouri H, Dalmais B, Laughton C, et al.
Nucleic Acids Res
. 2013 Apr;
41(10):5303-20.
PMID: 23563155
Bacillus subtilis has two replicative DNA polymerases. PolC is a processive high-fidelity replicative polymerase, while the error-prone DnaEBs extends RNA primers before hand-off to PolC at the lagging strand. We...