Charles F McTiernan
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Explore the profile of Charles F McTiernan including associated specialties, affiliations and a list of published articles.
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70
Citations
1871
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Recent Articles
1.
Polsinelli V, Hanley-Yanez K, McTiernan C, Modi K, Haythe J, Skopicki H, et al.
Am Heart J Plus
. 2025 Jan;
49():100489.
PMID: 39811721
Objective: Evaluate the relationship of cathepsin-D (CD) on disease severity and clinical outcomes for women with peripartum cardiomyopathy. Background: Cathepsin-D is a protease released during oxidative stress that cleaves prolactin...
2.
Qu H, Delfiner M, Gangireddy C, Vaidya A, Nguyen K, Whitman I, et al.
J Mol Med (Berl)
. 2024 Dec;
103(2):175-185.
PMID: 39730912
In one of the earliest reports from China during COVID-19, it was noted that over 20% of patients hospitalized with the disease had significant elevations of troponin, a marker of...
3.
Martin T, Pak H, Gerhard G, Merali S, Merali C, Lemster B, et al.
J Am Heart Assoc
. 2023 Dec;
12(24):e029938.
PMID: 38108245
Background: Mutations to the co-chaperone protein BAG3 (B-cell lymphoma-2-associated athanogene-3) are a leading cause of dilated cardiomyopathy (DCM). These mutations often impact the C-terminal BAG domain (residues 420-499), which regulates...
4.
Wang J, Tomar D, Martin T, Dubey S, Dubey P, Song J, et al.
JACC Basic Transl Sci
. 2023 Aug;
8(7):820-839.
PMID: 37547075
B-cell lymphoma 2-associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many...
5.
Zhang M, Feng N, Peng Z, Thapa D, Stoner M, Manning J, et al.
iScience
. 2023 Jun;
26(6):106942.
PMID: 37305705
General control of amino acid synthesis 5-like 1 (GCN5L1) was previously identified as a key regulator of protein lysine acetylation in mitochondria. Subsequent studies demonstrated that GCN5L1 regulates the acetylation...
6.
Xu Q, Rose J, Chen X, Wang L, DeMartino A, Dent M, et al.
JCI Insight
. 2022 Sep;
7(21).
PMID: 36173682
I.v. administration of a high-affinity carbon monoxide-binding (CO-binding) molecule, recombinant neuroglobin, can improve survival in CO poisoning mouse models. The current study aims to discover how biochemical variables of the...
7.
Carew N, Schmidt H, Yuan S, Galley J, Hall R, Altmann H, et al.
J Clin Invest
. 2022 Sep;
132(18).
PMID: 36106636
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing...
8.
Clerk A, Meijles D, Hardyman M, Fuller S, Chothani S, Cull J, et al.
Biochem J
. 2022 Feb;
479(3):401-424.
PMID: 35147166
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if...
9.
Proinflammatory TH17 cytokine activation, disease severity and outcomes in peripartum cardiomyopathy
Koczo A, Marino A, Rocco J, Ewald G, Givertz M, Rajagopalan N, et al.
Int J Cardiol
. 2021 Jul;
339:93-98.
PMID: 34224767
Background: Immune dysregulation is implicated in the development and clinical outcomes of peripartum cardiomyopathy (PPCM). Methods And Results: 98 women with PPCM were enrolled and followed for 1 year postpartum...
10.
Sharifi-Sanjani M, Berman M, Goncharov D, Alhamaydeh M, Avolio T, Baust J, et al.
Int J Mol Sci
. 2021 Jul;
22(11).
PMID: 34200497
Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive fibrosis. Transcriptional co-activator Yes-associated protein (Yap), the...