Mark T Gladwin
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Explore the profile of Mark T Gladwin including associated specialties, affiliations and a list of published articles.
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476
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24376
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Recent Articles
1.
Shah S, Bonderman D, Borlaug B, Cleland J, Lack G, Lu W, et al.
Circ Heart Fail
. 2025 Mar;
:e011381.
PMID: 40066571
Background: Despite favorable hemodynamic and neurohormonal effects, endothelin receptor antagonists have not improved outcomes in patients with heart failure (HF), possibly because they cause fluid retention. Methods: In this randomized,...
2.
Reisz J, Earley E, Nemkov T, Key A, Stephenson D, Keele G, et al.
Aging Cell
. 2024 Oct;
24(2):e14388.
PMID: 39478346
Increasing global life expectancy motivates investigations of molecular mechanisms of aging and age-related diseases. This study examines age-associated changes in red blood cells (RBCs), the most numerous host cell in...
3.
Chowdhury F, Sharma M, Schafer D, Nouraie S, Gladwin M, Straub A, et al.
Blood Adv
. 2024 Oct;
8(23):6098-6103.
PMID: 39374579
No abstract available.
4.
Grazioli A, Rabin J, Rector R, Wu Z, Burke A, Sharifai N, et al.
J Intensive Care Med
. 2024 Aug;
:8850666241260605.
PMID: 39140386
Sickle cell disease (SCD) is associated with substantial morbidity and early mortality in afflicted adults. Cardiopulmonary complications that occur at increased frequency in SCD such as pulmonary embolism, pulmonary arterial...
5.
Jheng J, Bai Y, Noda K, Huot J, Cook T, Fisher A, et al.
Circulation
. 2024 May;
150(11):867-883.
PMID: 38804138
Background: Pulmonary hypertension (PH) is a major complication linked to adverse outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies exist for PH associated with HFpEF...
6.
Hersi K, Ramani G, Law J, Sadek A, Vaidya A, Gladwin M, et al.
Pulm Circ
. 2024 May;
14(2):e12362.
PMID: 38803827
Pulmonary hypertension in sickle cell disease (SCD) is a complex phenomenon resulting from multiple overlapping etiologies, including pulmonary vasoconstriction in the setting of chronic hemolytic anemia, diastolic dysfunction, and chronic...
7.
Keener R, Chhetri S, Connelly C, Taub M, Conomos M, Weinstock J, et al.
Nat Commun
. 2024 May;
15(1):4417.
PMID: 38789417
Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere...
8.
Zuchelkowski B, Penaloza H, Xiong Z, Wang L, Cifuentes-Pagano E, Rochon E, et al.
Res Sq
. 2024 Apr;
PMID: 38559268
The X-linked A variant (rs1050828, Val68Met) in accounts for glucose-6-phosphate (G6PD) deficiency in approximately 11% of African American males. This common, hypomorphic variant may impact pulmonary host defense and phagocyte...
9.
Gladwin M, Gordeuk V, Desai P, Minniti C, Novelli E, Morris C, et al.
Lancet Haematol
. 2024 Mar;
11(5):e345-e357.
PMID: 38554715
Background: Although nitric oxide based therapeutics have been shown in preclinical models to reduce vaso-occlusive events and improve cardiovascular function, a clinical trial of a phosphodiesterase 5 inhibitor increased rates...
10.
Wang L, Rochon E, Gingras S, Zuchelkowski B, Sinchar D, Alipour E, et al.
Transfusion
. 2024 Feb;
64(4):615-626.
PMID: 38400625
Background: Donor genetic variation is associated with red blood cell (RBC) storage integrity and post-transfusion recovery. Our previous large-scale genome-wide association study demonstrated that the African G6PD deficient A- variant...