Charles E Petersen
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Explore the profile of Charles E Petersen including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
140
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Recent Articles
1.
Tkachenko S, Okun I, Balakin K, Petersen C, Ivanenkov Y, Savchuk N, et al.
Curr Drug Discov Technol
. 2006 Feb;
1(3):201-10.
PMID: 16472247
Primary high-throughput screening of commercially available small molecules collections often results in hit compounds with unfavorable ADME/Tox properties and low IP potential. These issues are addressed empirically at follow-up lead...
2.
Siemiarczuk A, Petersen C, Ha C, Yang J, Bhagavan N
Cell Biochem Biophys
. 2004 Apr;
40(2):115-22.
PMID: 15054218
Tryptophan 214, the only tryptophan residue in human serum albumin, is located in the physiologically important subdomain 2A ligand binding site. In the present study the fluorescence lifetime of tryptophan...
3.
Petitpas I, Petersen C, Ha C, Bhattacharya A, Zunszain P, Ghuman J, et al.
Proc Natl Acad Sci U S A
. 2003 May;
100(11):6440-5.
PMID: 12743361
Human serum albumin (HSA) is the major protein component of blood plasma and serves as a transporter for thyroxine and other hydrophobic compounds such as fatty acids and bilirubin. We...
4.
Ha J, Ha C, Chao J, Petersen C, Theriault A, Bhagavan N
Biochim Biophys Acta
. 2003 May;
1640(2-3):119-28.
PMID: 12729921
In the present study, we used the human EA.hy926 endothelial cell line as the model system to investigate the effect of human serum albumin (HSA) and its structural variants on...
5.
The role of electrostatic interactions in human serum albumin binding and stabilization by halothane
Liu R, Pidikiti R, Ha C, Petersen C, Bhagavan N, Eckenhoff R
J Biol Chem
. 2002 Jul;
277(39):36373-9.
PMID: 12118010
Electrostatic interactions have been proposed as a potentially important force for anesthetics and protein binding but have not yet been tested directly. In the present study, we used wild-type human...
6.
Petersen C, Ha C, Curry S, Bhagavan N
Proteins
. 2002 Apr;
47(2):116-25.
PMID: 11933059
The binding of warfarin to the following human serum albumin (HSA) mutants was examined: K195M, K199M, F211V, W214L, R218M, R222M, H242V, and R257M. Warfarin bound to human serum albumin (HSA)...
7.
Subramaniam R, Fan X, Scivittaro V, Yang J, Ha C, Petersen C, et al.
Arch Biochem Biophys
. 2002 Mar;
400(1):15-25.
PMID: 11913966
In order to understand the mechanism by which advanced glycation endproducts (AGEs) elicit oxidative stress, macrophage-like RAW264.7 cells were exposed to various AGE-albumins, and oxidant stress was estimated from the...
8.
Yang J, Petersen C, Ha C, Bhagavan N
Protein Sci
. 2002 Feb;
11(3):538-45.
PMID: 11847277
Previous studies have shown that many arachidonic acid metabolites bind to human serum albumin (HSA) and that the metabolism of these molecules is altered as a result of binding. The...
9.
Harohalli K, Petersen C, Ha C, Feix J, Bhagavan N
J Biomed Sci
. 2002 Jan;
9(1):47-58.
PMID: 11810025
The patterns of nitric oxide (NO) release from nitrosated bovine serum albumin (BSA), human serum albumin (HSA) and a number of recombinant HSA mutants were compared. All albumin species were...