Charles E McKenna
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Explore the profile of Charles E McKenna including associated specialties, affiliations and a list of published articles.
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121
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1820
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Recent Articles
11.
Kremen Jr T, Shi B, Wu S, Sundberg O, Sriram V, Kim W, et al.
J Orthop Res
. 2023 Apr;
41(10):2250-2260.
PMID: 37087676
Tendon injuries are common and often treated surgically, however, current tendon repair healing results in poorly organized fibrotic tissue. While certain growth factors have been reported to improve both the...
12.
Sedghizadeh P, Cherian P, Roshandel S, Tjokro N, Chen C, Junka A, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768310
Osteomyelitis is a limb- and life-threatening orthopedic infection predominantly caused by biofilms. Bone infections are extremely challenging to treat clinically. Therefore, we have been designing, synthesizing, and testing novel antibiotic...
13.
Zhou Y, Overhulse J, Dupper N, Guo Y, Kashemirov B, Wei K, et al.
J Comput Chem
. 2022 Oct;
43(32):2121-2130.
PMID: 36190786
Novel agents to treat invasive fungal infections are urgently needed because the small number of established targets in pathogenic fungi makes the existing drug repertoire particularly vulnerable to the emergence...
14.
Kondo T, Okawa H, Hokugo A, Shokeen B, Sundberg O, Zheng Y, et al.
Commun Biol
. 2022 Sep;
5(1):962.
PMID: 36104423
Periodontitis is a highly prevalent disease leading to uncontrolled osteoclastic jawbone resorption and ultimately edentulism; however, the disease onset mechanism has not been fully elucidated. Here we propose a mechanism...
15.
Okawa H, Kondo T, Hokugo A, Cherian P, Sundberg O, Campagna J, et al.
Commun Med (Lond)
. 2022 Sep;
2:112.
PMID: 36082175
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare but serious side effect of nitrogen-containing bisphosphonate drugs (N-BPs) frequently prescribed to reduce skeletal-related events in bone malignancies and osteoporosis....
16.
Okawa H, Kondo T, Hokugo A, Cherian P, Campagna J, Lentini N, et al.
Elife
. 2022 Aug;
11.
PMID: 36017995
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is rare, BRONJ has caused apprehension among patients...
17.
Ebetino F, Sun S, Cherian P, Roshandel S, Neighbors J, Hu E, et al.
Bone
. 2021 Dec;
156:116289.
PMID: 34896359
The bisphosphonates ((HO)P(O)CRRP(O)(OH), BPs) were first shown to inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed molecular understanding of the relationship...
18.
Kempfle J, Duro M, Zhang A, Amador C, Kuang R, Lu R, et al.
Front Cell Neurosci
. 2021 Aug;
15:666706.
PMID: 34335184
Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival,...
19.
Pedowitz N, Jackson E, Overhulse J, McKenna C, Kohler J, Pratt M
ACS Chem Biol
. 2021 Jul;
16(10):1924-1929.
PMID: 34282887
Metabolic chemical reports have fundamentally changed the way researchers study glycosylation. However, when administered as per--acetylated sugars, reporter molecules can participate in nonspecific chemical labeling of cysteine residues termed -glycosylation....
20.
Adjei-Sowah E, Peng Y, Weeks J, Jonason J, Bentley K, Masters E, et al.
Antibiotics (Basel)
. 2021 Jul;
10(6).
PMID: 34204351
The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about colonization of the osteocyte-lacuno canalicular network (OLCN)....