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Charles B Stephensen

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Articles 109
Citations 2331
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Recent Articles
11.
Kable M, Chin E, Huang L, Stephensen C, Lemay D
J Nutr . 2023 Jun; 153(8):2163-2173. PMID: 37354976
Background: Lactase persistence (LP) is a heritable trait in which lactose can be digested throughout adulthood. Lactase nonpersistent (LNP) individuals who consume lactose may experience microbial adaptations in response to...
12.
Snodgrass R, Jiang X, Stephensen C, Laugero K
Immun Ageing . 2023 Jun; 20(1):29. PMID: 37353855
Background: Progressive age-associated change in frequencies and functional capacities of immune cells is known as immunosenescence. Despite data linking chronic environmental, physiological, and psychosocial stressors with accelerated aging, how stress...
13.
Larke J, Bacalzo N, Castillo J, Couture G, Chen Y, Xue Z, et al.
J Nutr . 2023 Mar; 153(1):106-119. PMID: 36913444
Background: Current assessment of dietary carbohydrates does not adequately reflect the nutritional properties and effects on gut microbial structure and function. Deeper characterization of food carbohydrate composition can serve to...
14.
Yang Z, Wang Y, Kirschke C, Stephensen C, Newman J, Keim N, et al.
J Trace Elem Med Biol . 2023 Feb; 77:127142. PMID: 36827808
Background: The common C-allele of rs13266634 (c.973C>T or p.Arg325Trp) in SLC30A8 (ZNT8) is associated with increased risk of type 2 diabetes. While previous studies have examined the correlation of the...
15.
James K, Gertz E, Kirschke C, Allayee H, Huang L, Kable M, et al.
Int J Mol Sci . 2023 Feb; 24(3). PMID: 36768394
Plasma trimethylamine n-oxide (TMAO) concentration increases in responses to feeding TMAO, choline, phosphatidylcholine, L-carnitine, and betaine but it is unknown whether concentrations change following a mixed macronutrient tolerance test (MMTT)...
16.
Krishnan S, Freytag T, Jiang X, Schuster G, Woodhouse L, Keim N, et al.
BMC Nutr . 2022 Dec; 8(1):157. PMID: 36575541
Objective: To evaluate the effect of a diet pattern based on Dietary Guidelines for Americans (DGA), in a controlled feeding setting, on plasma markers of inflammation and on cytokine production...
17.
Riazati N, Kable M, Newman J, Adkins Y, Freytag T, Jiang X, et al.
Front Immunol . 2022 Oct; 13:917966. PMID: 36248784
Background: Tryptophan (Trp) metabolites from intestinal bacteria (indole, indole acetic acid [IAA] and indole propionic acid [IPA]), and the Trp metabolite kynurenine (Kyn) from the indoleamine 2,3-dioxygenase (IDO) pathway, are...
18.
Calder P, Ortega E, Meydani S, Adkins Y, Stephensen C, Thompson B, et al.
Adv Nutr . 2022 Oct; 13(5):S1-S26. PMID: 36183242
The immune system is key to host defense against pathogenic organisms. Aging is associated with changes in the immune system, with a decline in protective components (immunosenescence), increasing susceptibility to...
19.
Kewcharoenwong C, Sein M, Nithichanon A, Khongmee A, Wessells K, Hinnouho G, et al.
Sci Rep . 2022 Sep; 12(1):16084. PMID: 36167891
Zinc deficiency impairs the antibody-mediated immune response and is common in children from lower-income countries. This study aimed to investigate the impact of different zinc supplementation regimens (7, 10 or...
20.
Snodgrass R, Jiang X, Stephensen C
Immun Ageing . 2022 Sep; 19(1):41. PMID: 36104734
Background: Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age. Although much of our current understanding of the age-related changes in...