Charles-Henri Lecellier
Overview
Explore the profile of Charles-Henri Lecellier including associated specialties, affiliations and a list of published articles.
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39
Citations
1695
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Recent Articles
1.
Deleuze V, Stephen T, Salma M, Orfeo C, Jorna R, Maas A, et al.
Sci Rep
. 2025 Mar;
15(1):8996.
PMID: 40089598
Genome-wide association studies (GWAS) have identified numerous genetic variants linked to human diseases, mostly located in non-coding regions of the genome, particularly in putative enhancers. However, functional assessment of the...
2.
Romero R, Menichelli C, Vroland C, Marin J, Lebre S, Lecellier C, et al.
Genome Biol
. 2024 Jul;
25(1):187.
PMID: 38987807
Characterizing the binding preferences of transcription factors (TFs) in different cell types and conditions is key to understand how they orchestrate gene expression. Here, we develop TFscope, a machine learning...
3.
Cassan O, Lecellier C, Martin A, Brehelin L, Lebre S
Bioinformatics
. 2024 Jun;
40(7).
PMID: 38913855
Motivations: Gene regulatory networks (GRNs) are traditionally inferred from gene expression profiles monitoring a specific condition or treatment. In the last decade, integrative strategies have successfully emerged to guide GRN...
4.
Hussain S, Sadouni N, van Essen D, Dao L, Ferre Q, Charbonnier G, et al.
Nucleic Acids Res
. 2023 Mar;
51(10):4845-4866.
PMID: 36929452
The action of cis-regulatory elements with either activation or repression functions underpins the precise regulation of gene expression during normal development and cell differentiation. Gene activation by the combined activities...
5.
Safieddine A, Coleno E, Lionneton F, Traboulsi A, Salloum S, Lecellier C, et al.
Nat Protoc
. 2022 Oct;
18(1):157-187.
PMID: 36280749
The ability to visualize RNA in its native subcellular environment by using single-molecule fluorescence in situ hybridization (smFISH) has reshaped our understanding of gene expression and cellular functions. A major...
6.
Grapotte M, Saraswat M, Bessiere C, Menichelli C, Ramilowski J, Severin J, et al.
Nat Commun
. 2022 Mar;
13(1):1200.
PMID: 35232988
No abstract available.
7.
Grapotte M, Saraswat M, Bessiere C, Menichelli C, Ramilowski J, Severin J, et al.
Nat Commun
. 2021 Jun;
12(1):3297.
PMID: 34078885
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of...
8.
Menichelli C, Guitard V, Martins R, Lebre S, Lopez-Rubio J, Lecellier C, et al.
PLoS Comput Biol
. 2021 Apr;
17(4):e1008909.
PMID: 33861755
Long regulatory elements (LREs), such as CpG islands, polydA:dT tracts or AU-rich elements, are thought to play key roles in gene regulation but, as opposed to conventional binding sites of...
9.
Safieddine A, Coleno E, Salloum S, Imbert A, Traboulsi A, Kwon O, et al.
Nat Commun
. 2021 Mar;
12(1):1352.
PMID: 33649340
Local translation allows for a spatial control of gene expression. Here, we use high-throughput smFISH to screen centrosomal protein-coding genes, and we describe 8 human mRNAs accumulating at centrosomes. These...
10.
Bejjani F, Tolza C, Boulanger M, Downes D, Romero R, Maqbool M, et al.
Nucleic Acids Res
. 2021 Feb;
49(5):2488-2508.
PMID: 33533919
The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how...