Charity W Law
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Explore the profile of Charity W Law including associated specialties, affiliations and a list of published articles.
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23
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22609
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Recent Articles
1.
Dong X, Du M, Gouil Q, Tian L, Jabbari J, Bowden R, et al.
Nat Methods
. 2023 Oct;
20(11):1810-1821.
PMID: 37783886
The lack of benchmark data sets with inbuilt ground-truth makes it challenging to compare the performance of existing long-read isoform detection and differential expression analysis workflows. Here, we present a...
2.
You Y, Dong X, Wee Y, Maxwell M, Alhamdoosh M, Smyth G, et al.
Genome Biol
. 2023 May;
24(1):112.
PMID: 37173797
No abstract available.
3.
You Y, Dong X, Wee Y, Maxwell M, Alhamdoosh M, Smyth G, et al.
Genome Biol
. 2023 May;
24(1):107.
PMID: 37147723
Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and its presence can hamper the detection of differentially expressed genes. Since most bulk RNA-seq methods assume equal group variances,...
4.
Kariyawasam H, Su S, Voogd O, Ritchie M, Law C
NAR Genom Bioinform
. 2022 Jan;
3(4):lqab116.
PMID: 34988439
1.0 introduced intuitive, point-and-click interactive graphics for differential gene expression analysis. Here, we present a major update to that brings improved interactivity and reproducibility using high-level visualization frameworks for R...
5.
Tian L, Jabbari J, Thijssen R, Gouil Q, Amarasinghe S, Voogd O, et al.
Genome Biol
. 2021 Nov;
22(1):310.
PMID: 34763716
A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing together with a new computational pipeline (FLAMES) is developed to enable isoform discovery, splicing...
6.
Chappaz S, McArthur K, Kealy L, Law C, Tailler M, Lane R, et al.
Cell Rep
. 2021 Jul;
36(3):109430.
PMID: 34289356
While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature B cell homeostasis remains elusive. Using mice...
7.
Ah-Cann C, Wimmer V, Weeden C, Marceaux C, Law C, Galvis L, et al.
Development
. 2021 Jun;
148(13).
PMID: 34121118
Development of a branching tree in the embryonic lung is crucial for the formation of a fully mature functional lung at birth. Sox9+ cells present at the tip of the...
8.
Dong X, Tian L, Gouil Q, Kariyawasam H, Su S, De Paoli-Iseppi R, et al.
NAR Genom Bioinform
. 2021 May;
3(2):lqab028.
PMID: 33937765
Application of Oxford Nanopore Technologies' long-read sequencing platform to transcriptomic analysis is increasing in popularity. However, such analysis can be challenging due to the high sequence error and small library...
9.
Verzele N, Chua B, Law C, Zhang A, Ritchie M, Wightman O, et al.
FASEB J
. 2021 Mar;
35(3):e21320.
PMID: 33660333
Influenza A virus (IAV) is rapidly detected in the airways by the immune system, with resident parenchymal cells and leukocytes orchestrating viral sensing and the induction of antiviral inflammatory responses....
10.
Law C, Zeglinski K, Dong X, Alhamdoosh M, Smyth G, Ritchie M
F1000Res
. 2021 Feb;
9:1444.
PMID: 33604029
Differential expression analysis of genomic data types, such as RNA-sequencing experiments, use linear models to determine the size and direction of the changes in gene expression. For RNA-sequencing, there are...