Charina M Ramirez
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Explore the profile of Charina M Ramirez including associated specialties, affiliations and a list of published articles.
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16
Citations
391
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Recent Articles
11.
Mundy D, Lopez A, Posey K, Chuang J, Ramirez C, Scherer P, et al.
Biochim Biophys Acta
. 2014 Apr;
1841(7):995-1002.
PMID: 24747682
Caveolin-1 (Cav-1) is a major structural protein in caveolae in the plasma membranes of many cell types, particularly endothelial cells and adipocytes. Loss of Cav-1 function has been implicated in...
12.
Ramirez C, Lopez A, Le L, Posey K, Weinberg A, Turley S
Biochim Biophys Acta
. 2013 Oct;
1841(1):54-61.
PMID: 24076310
Niemann-Pick Type C (NPC) disease is caused by a deficiency of either NPC1 or NPC2. Loss of function of either protein results in the progressive accumulation of unesterified cholesterol in...
13.
Aqul A, Liu B, Ramirez C, Pieper A, Estill S, Burns D, et al.
J Neurosci
. 2011 Jun;
31(25):9404-13.
PMID: 21697390
While unesterified cholesterol (C) is essential for remodeling neuronal plasma membranes, its role in certain neurodegenerative disorders remains poorly defined. Uptake of sterol from pericellular fluid requires processing that involves...
14.
Ramirez C, Liu B, Aqul A, Taylor A, Repa J, Turley S, et al.
J Lipid Res
. 2011 Feb;
52(4):688-98.
PMID: 21289032
Lipoprotein cholesterol taken up by cells is processed in the endosomal/lysosomal (E/L) compartment by the sequential action of lysosomal acid lipase (LAL), Niemann-Pick C2 (NPC2), and Niemann-Pick C1 (NPC1). Inactivation...
15.
Ramirez C, Liu B, Taylor A, Repa J, Burns D, Weinberg A, et al.
Pediatr Res
. 2010 Jun;
68(4):309-15.
PMID: 20581737
Niemann-Pick type C1 (NPC1) disease arises from a mutation inactivating NPC1 protein that normally moves unesterified cholesterol from the late endosomal/lysosomal complex of cells to the cytosolic compartment for processing....
16.
Liu B, Ramirez C, Miller A, Repa J, Turley S, Dietschy J
J Lipid Res
. 2009 Dec;
51(5):933-44.
PMID: 19965601
A mutation in NPC1 leads to sequestration of unesterified cholesterol in the late endosomal/lysosomal compartment of every cell culminating in the development of pulmonary, hepatic, and neurodegenerative disease. Acute administration...