Chandra Sekhar Boddupalli
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Explore the profile of Chandra Sekhar Boddupalli including associated specialties, affiliations and a list of published articles.
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14
Citations
770
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Recent Articles
1.
Boddupalli C, Nair S, Belinsky G, Gans J, Teeple E, Nguyen T, et al.
Elife
. 2022 Aug;
11.
PMID: 35972072
Background: Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features;...
2.
Nair S, Sng J, Boddupalli C, Seckinger A, Chesi M, Fulciniti M, et al.
JCI Insight
. 2018 Apr;
3(8).
PMID: 29669929
A role for antigen-driven stimulation has been proposed in the pathogenesis of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) based largely on the binding properties of monoclonal...
3.
Branagan A, Duffy E, Albrecht R, Cooper D, Seropian S, Parker T, et al.
Clin Lymphoma Myeloma Leuk
. 2017 Mar;
17(5):296-304.e2.
PMID: 28343904
Background: Patients with multiple myeloma (MM) and other plasma cell disorders are highly susceptible to influenza infections, which are major causes of morbidity in this population, despite the routine administration...
4.
Boddupalli C, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, et al.
JCI Insight
. 2016 Dec;
1(21):e88955.
PMID: 28018970
Heterogeneity of tumor cells and their microenvironment can affect outcome in cancer. Blockade of immune checkpoints (ICPs) expressed only on a subset of immune cells leads to durable responses in...
5.
Boddupalli C, Nair S, Gray S, Nowyhed H, Verma R, Gibson J, et al.
J Clin Invest
. 2016 Sep;
126(10):3905-3916.
PMID: 27617863
Immune surveillance in tissues is mediated by a long-lived subset of tissue-resident memory T cells (Trm cells). A putative subset of tissue-resident long-lived stem cells is characterized by the ability...
6.
Nair S, Branagan A, Liu J, Boddupalli C, Mistry P, Dhodapkar M
N Engl J Med
. 2016 Feb;
374(6):555-61.
PMID: 26863356
Antigen-driven selection has been implicated in the pathogenesis of monoclonal gammopathies. Patients with Gaucher's disease have an increased risk of monoclonal gammopathies. Here we show that the clonal immunoglobulin in...
7.
Sureshbabu A, Syed M, Boddupalli C, Dhodapkar M, Homer R, Minoo P, et al.
Respir Res
. 2015 Jan;
16:4.
PMID: 25591994
Background: Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a...
8.
Das R, Verma R, Sznol M, Boddupalli C, Gettinger S, Kluger H, et al.
J Immunol
. 2014 Dec;
194(3):950-9.
PMID: 25539810
Combination therapy concurrently targeting PD-1 and CTLA-4 immune checkpoints leads to remarkable antitumor effects. Although both PD-1 and CTLA-4 dampen the T cell activation, the in vivo effects of these...
9.
Nair S, Boddupalli C, Verma R, Liu J, Yang R, Pastores G, et al.
Blood
. 2014 Dec;
125(8):1256-71.
PMID: 25499455
Chronic inflammation including B-cell activation is commonly observed in both inherited (Gaucher disease [GD]) and acquired disorders of lipid metabolism. However, the cellular mechanisms underlying B-cell activation in these settings...
10.
Bolisetty S, Boddupalli C, Handschin S, Chaitanya K, Adamcik J, Saito Y, et al.
Biomacromolecules
. 2014 Jun;
15(7):2793-9.
PMID: 24941321
Amyloid protein fibrils occur in vivo as pathological agents, in the case of neurodegenerative diseases, or as functional amyloids, when playing biologically vital roles. Here we show how amyloid fibrils...