Chanan Rubin
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Explore the profile of Chanan Rubin including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Zofall M, Yamanaka S, Reyes-Turcu F, Zhang K, Rubin C, Grewal S
Science
. 2011 Dec;
335(6064):96-100.
PMID: 22144463
Facultative heterochromatin that changes during cellular differentiation coordinates regulated gene expression, but its assembly is poorly understood. Here, we describe facultative heterochromatin islands in fission yeast and show that their...
2.
Fischer T, Cui B, Dhakshnamoorthy J, Zhou M, Rubin C, Zofall M, et al.
Proc Natl Acad Sci U S A
. 2009 May;
106(22):8998-9003.
PMID: 19443688
Conserved chromosomal HP1 proteins capable of binding to histone H3 methylated at lysine 9 are believed to provide a dynamic platform for the recruitment and/or spreading of various regulatory proteins...
3.
Starr A, Greif J, Vexler A, Ashkenazy-Voghera M, Gladesh V, Rubin C, et al.
Int J Cancer
. 2006 Feb;
119(2):269-74.
PMID: 16463386
Clinical and experimental data suggest that ErbB-4, a member of the epidermal growth factor receptor family, may have a role in cancer progression and response to treatment. We found recently,...
4.
Rubin C, Gur G, Yarden Y
Cell Res
. 2005 Feb;
15(1):66-71.
PMID: 15686631
Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for...
5.
Rubin C, Zwang Y, Vaisman N, Ron D, Yarden Y
J Biol Chem
. 2005 Jan;
280(10):9735-44.
PMID: 15637081
Sprouty proteins are evolutionarily conserved negative feedback regulators of multiple receptor tyrosine kinases. Mammalian versions of these proteins differentially regulate signaling induced by the fibroblast and the epidermal growth factors...
6.
Gur G, Rubin C, Katz M, Amit I, Citri A, Nilsson J, et al.
EMBO J
. 2004 Jul;
23(16):3270-81.
PMID: 15282549
Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane protein whose inactivation in rodents promotes skin...
7.
Penengo L, Rubin C, Yarden Y, Gaudino G
Oncogene
. 2003 Jun;
22(24):3669-79.
PMID: 12802274
Ron, the receptor tyrosine kinase (RTK) for the macrophage stimulating protein (MSP), activates multiple signaling pathways by recruiting several positive regulators to a multifunctional docking site. Here we show that...
8.
Rubin C, Litvak V, Medvedovsky H, Zwang Y, Lev S, Yarden Y
Curr Biol
. 2003 Feb;
13(4):297-307.
PMID: 12593795
Background: Growth factors and their receptor tyrosine kinases play pivotal roles in development, normal physiology, and pathology. Signal transduction is regulated primarily by receptor endocytosis and degradation in lysosomes ("receptor...
9.
Citri A, Alroy I, Lavi S, Rubin C, Xu W, Grammatikakis N, et al.
EMBO J
. 2002 May;
21(10):2407-17.
PMID: 12006493
Overexpression of ErbB-2/HER2 is associated with aggressive human malignancies, and therapeutic strategies targeting the oncoprotein are currently in different stages of clinical application. Tyrosine kinase inhibitors (TKIs) that block the...
10.
Waterman H, Katz M, Rubin C, Shtiegman K, Lavi S, Elson A, et al.
EMBO J
. 2002 Feb;
21(3):303-13.
PMID: 11823423
Ligand-induced desensitization of the epidermal growth factor receptor (EGFR) is controlled by c-Cbl, a ubiquitin ligase that binds multiple signaling proteins, including the Grb2 adaptor. Consistent with a negative role...