Chan-Wang J Lio
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Explore the profile of Chan-Wang J Lio including associated specialties, affiliations and a list of published articles.
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22
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2248
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Recent Articles
1.
Read K, Jones D, Pokhrel S, Hales E, Varkey A, Tuazon J, et al.
Nat Commun
. 2023 Mar;
14(1):1652.
PMID: 36964178
During intracellular infection, T follicular helper (T) and T helper 1 (T1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions...
2.
Seo H, Gonzalez-Avalos E, Zhang W, Ramchandani P, Yang C, Lio C, et al.
Nat Immunol
. 2021 Jul;
22(8):983-995.
PMID: 34282330
The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-1; Fos-Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence...
3.
Takahashi M, Lio C, Campeau A, Steger M, Ay F, Mann M, et al.
Nat Immunol
. 2021 Mar;
22(4):485-496.
PMID: 33767426
Evasion of host immunity is a hallmark of cancer; however, mechanisms linking oncogenic mutations and immune escape are incompletely understood. Through loss-of-function screening of 1,001 tumor suppressor genes, we identified...
4.
Lio C, Yue X, Lopez-Moyado I, Tahiliani M, Aravind L, Rao A
J Biosci
. 2020 Jan;
45.
PMID: 31965999
In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in...
5.
Lio C, Yuita H, Rao A
Blood
. 2019 Aug;
134(18):1487-1497.
PMID: 31467060
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation, and cancer. Cancer cells display highly dysregulated DNA methylation profiles, characterized by global hypomethylation in...
6.
Yue X, Lio C, Samaniego-Castruita D, Li X, Rao A
Nat Commun
. 2019 May;
10(1):2011.
PMID: 31043609
TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine and other oxidized methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) cells. Tet2/3Foxp3 mice lacking Tet2 and...
7.
Lio C, Shukla V, Samaniego-Castruita D, Gonzalez-Avalos E, Chakraborty A, Yue X, et al.
Sci Immunol
. 2019 Apr;
4(34).
PMID: 31028100
TET enzymes are dioxygenases that promote DNA demethylation by oxidizing the methyl group of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Here, we report a close correspondence between 5hmC-marked regions, chromatin accessibility and...
8.
Chen J, Lopez-Moyado I, Seo H, Lio C, Hempleman L, Sekiya T, et al.
Nature
. 2019 Mar;
567(7749):530-534.
PMID: 30814732
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies. CAR T cells have been less effective against solid...
9.
Lio C, Rao A
Front Immunol
. 2019 Feb;
10:210.
PMID: 30809228
DNA methylation is an abundant and stable epigenetic modification that allows inheritance of information from parental to daughter cells. At active genomic regions, DNA methylation can be reversed by TET...
10.
Scott-Browne J, Lio C, Rao A
Curr Opin Genet Dev
. 2017 Sep;
46:202-208.
PMID: 28888139
The ten-eleven-translocation (TET) proteins oxidize 5-methylcytosine in DNA. Alterations in TET protein function have been linked to cancer, but TETs have also been observed to influence many cell differentiation processes....