Ageliki Tsagaratou
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Explore the profile of Ageliki Tsagaratou including associated specialties, affiliations and a list of published articles.
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27
Citations
831
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Recent Articles
1.
Zaiken M, Jin S, McDonald-Hyman C, Hartigan C, Sage P, Hippen K, et al.
Blood
. 2025 Feb;
PMID: 39899881
Chronic graft-versus-host disease (cGVHD) is the leading cause of morbidity and non-relapse associated mortality following allogeneic hematopoietic cell transplantation (aHSCT). Treating steroid resistant/refractory cGVHD remains challenging. Epigenetic regulators can have...
2.
Gioulbasani M, Aijo T, Liu S, Montgomery S, Montgomery N, Corcoran D, et al.
Commun Biol
. 2024 Dec;
7(1):1606.
PMID: 39627458
Ten eleven translocation (TET) proteins are tumor suppressors that through their catalytic activity oxidize 5-methylcytosine to 5-hydroxymethylcytosine, to promote DNA demethylation and to regulate gene expression. Notably, TET2 is one...
3.
Gioulbasani M, Aijo T, Valenzuela J, Bettes J, Tsagaratou A
Front Immunol
. 2024 Oct;
15:1440044.
PMID: 39364402
DNA demethylases TET2 and TET3 play a fundamental role in thymic invariant natural killer T (iNKT) cell differentiation by mediating DNA demethylation of genes encoding for lineage specifying factors. Paradoxically,...
4.
Zhou X, Wang Y, Dou Z, Delfanti G, Tsahouridis O, Pellegry C, et al.
Nat Cancer
. 2024 Oct;
5(11):1607-1621.
PMID: 39354225
Human natural killer T (NKT) cells have been proposed as a promising cell platform for chimeric antigen receptor (CAR) therapy in solid tumors. Here we generated murine CAR-NKT cells and...
5.
Gioulbasani M, Aijo T, Valenzuela J, Bettes J, Tsagaratou A
bioRxiv
. 2024 Aug;
PMID: 39131272
DNA demethylases TET2 and TET3 play a fundamental role in thymic invariant natural killer T (iNKT) cell differentiation by mediating DNA demethylation of genes encoding for lineage specifying factors. Paradoxically,...
6.
Theofilatos D, Ho T, Waitt G, Aijo T, Schiapparelli L, Soderblom E, et al.
iScience
. 2024 May;
27(5):109782.
PMID: 38711449
Ten-eleven translocation (TET) proteins are DNA dioxygenases that mediate active DNA demethylation. TET3 is the most highly expressed TET protein in thymic developing T cells. TET3, either independently or in...
7.
Gioulbasani M, Tsagaratou A
Curr Protoc
. 2023 Jul;
3(7):e838.
PMID: 37428873
This article discusses methods to assess invariant natural killer T (iNKT) cell subsets isolated from the thymus, as well as the spleen, the liver, and the lung. iNKT cells can...
8.
Tsagaratou A
Immunohorizons
. 2023 Jan;
7(1):106-115.
PMID: 36645853
Ten-eleven translocation (TET) proteins are dioxygenases that oxidize 5-methylcytosine to form 5-hydroxymethylcytosine and downstream oxidized modified cytosines. In the past decade, intensive research established that TET-mediated DNA demethylation is critical...
9.
Theofilatos D, Aijo T, Tsagaratou A
STAR Protoc
. 2022 Nov;
3(4):101839.
PMID: 36386867
Here, we describe steps to isolate mature thymic T cell subsets, namely CD4 single positive (SP), CD8 SP, and invariant natural killer T (iNKT) cells starting from murine total thymocytes...
10.
Aijo T, Theofilatos D, Cheng M, Smith M, Xiong Y, Baldwin A, et al.
Front Immunol
. 2022 Aug;
13:940995.
PMID: 35990681
TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously demonstrated a dynamic enrichment of 5hmC during T and invariant natural killer...