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Chae-Myeong Ha

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Articles 25
Citations 805
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Recent Articles
1.
Ha C, Bakshi S, Brahma M, Potter L, Chang S, Sun Z, et al.
J Am Heart Assoc . 2023 Sep; 12(19):e029898. PMID: 37750556
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification, the addition of -linked β-...
2.
Zou L, Zhang D, Ha C, Wende A, Chatham J
Am J Physiol Heart Circ Physiol . 2023 Aug; 325(4):H601-H616. PMID: 37539459
The modification of serine and threonine amino acids of proteins by -linked -acetylglucosamine (-GlcNAc) regulates the activity, stability, function, and subcellular localization of proteins. Dysregulation of -GlcNAc homeostasis is well...
3.
Chatham J, Ha C, Wende A
Cell Rep Methods . 2023 Aug; 3(7):100537. PMID: 37533649
In this issue of , Sunden et al. develop an enzymatic assay to measure UDP-GlcNAc levels from cells and tissue. By reporting on the level of the substrate itself, this...
4.
Riehle C, Sieweke J, Bakshi S, Ha C, Udesen N, Moller-Helgestad O, et al.
Front Cardiovasc Med . 2022 Jun; 9:881067. PMID: 35694659
Background: Cardiogenic shock (CS) alters whole body metabolism and circulating biomarkers serve as prognostic markers in CS patients. Percutaneous ventricular assist devices (pVADs) unload the left ventricle by actively ejecting...
5.
Ha C, Wende A
JACC Basic Transl Sci . 2021 Dec; 6(11):851-853. PMID: 34869948
No abstract available.
6.
Alsheikh H, Metge B, Ha C, Hinshaw D, Mota M, Kammerud S, et al.
Cancer Lett . 2021 May; 517:24-34. PMID: 34052331
Obesity and diabetes cumulatively create a distinct systemic metabolic pathophysiological syndrome that predisposes patients to several diseases including breast cancer. Moreover, diabetic and obese women with breast cancer show a...
7.
Pepin M, Ha C, Potter L, Bakshi S, Barchue J, Haj Asaad A, et al.
Am J Physiol Heart Circ Physiol . 2021 Mar; 320(5):H2066-H2079. PMID: 33769919
Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of patients with HF respond to guideline-directed medical management,...
8.
Brahma M, Ha C, Pepin M, Mia S, Sun Z, Chatham J, et al.
J Am Heart Assoc . 2020 Aug; 9(15):e013039. PMID: 32750298
Background Perturbations in myocardial substrate utilization have been proposed to contribute to the pathogenesis of cardiac dysfunction in diabetic subjects. The failing heart in nondiabetics tends to decrease reliance on...
9.
Wende A, Schell J, Ha C, Pepin M, Khalimonchuk O, Schwertz H, et al.
Diabetes . 2020 May; 69(10):2094-2111. PMID: 32366681
Cardiac glucose uptake and oxidation are reduced in diabetes despite hyperglycemia. Mitochondrial dysfunction contributes to heart failure in diabetes. It is unclear whether these changes are adaptive or maladaptive. To...
10.
Kim S, Song J, Ernst P, Latimer M, Ha C, Goh K, et al.
Am J Physiol Heart Circ Physiol . 2020 Feb; 318(3):H682-H695. PMID: 32004065
Evidence suggests that mitochondrial network integrity is impaired in cardiomyocytes from failing hearts. While oxidative stress has been implicated in heart failure (HF)-associated mitochondrial remodeling, the effect of mitochondrial-targeted antioxidants,...