Chad Lerner
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Explore the profile of Chad Lerner including associated specialties, affiliations and a list of published articles.
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10
Citations
242
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Recent Articles
1.
Labbe K, Mookerjee S, Le Vasseur M, Gibbs E, Lerner C, Nunnari J
J Cell Biol
. 2021 Sep;
220(11).
PMID: 34586346
Mitochondrial function is integrated with cellular status through the regulation of opposing mitochondrial fusion and division events. Here we uncover a link between mitochondrial dynamics and lipid metabolism by examining...
2.
Lei W, Lerner C, Sundar I, Rahman I
Sci Rep
. 2017 Mar;
7:43213.
PMID: 28256533
Nicotine is the major stimulant in tobacco products including e-cigarettes. Fibroblast to myofibroblast differentiation is a key process during wound healing and is dysregulated in lung diseases. The role of...
3.
Salmon A, Lerner C, Ikeno Y, Perrine S, McCarter R, Sell C
Am J Physiol Endocrinol Metab
. 2015 Feb;
308(7):E545-53.
PMID: 25648834
The extension of lifespan due to reduced insulin-like growth factor 1 (IGF-I) signaling in mice has been proposed to be mediated through alterations in metabolism. Previously, we showed that mice...
4.
Crowe E, Nacarelli T, Bitto A, Lerner C, Sell C, Torres C
Methods Mol Biol
. 2014 Jun;
1170:425-45.
PMID: 24906328
The detection of senescent cells has become an important area of research in the aging field. Due to the complexity of the senescence program and the lack of a unique...
5.
Bitto A, Crowe E, Lerner C, Torres C, Sell C
Methods Mol Biol
. 2014 Jun;
1170:145-54.
PMID: 24906313
All living organisms are subject to progressive loss of function and damage to their tissues, a process known as aging. At the cellular level, the accumulation of damage to DNA,...
6.
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
Yao H, Sundar I, Ahmad T, Lerner C, Gerloff J, Friedman A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2014 Mar;
306(9):L816-28.
PMID: 24633890
Oxidative and carbonyl stress is increased in lungs of smokers and patients with chronic obstructive pulmonary disease (COPD), as well as in cigarette smoke (CS)-exposed rodent lungs. We previously showed...
7.
Lorenzini A, Salmon A, Lerner C, Torres C, Ikeno Y, Motch S, et al.
J Gerontol A Biol Sci Med Sci
. 2013 Jul;
69(4):410-9.
PMID: 23873963
Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life...
8.
Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, et al.
Aging Cell
. 2013 Jun;
12(6):966-77.
PMID: 23795962
Coordinated expression of mitochondrial and nuclear genes is required to maintain proper mitochondrial function. However, the precise mechanisms that ensure this coordination are not well defined. We find that signaling...
9.
Fink L, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, et al.
Aging (Albany NY)
. 2011 Sep;
3(9):836-45.
PMID: 21931182
Faithful repair of damaged DNA is a crucial process in maintaining cell viability and function. A multitude of factors and pathways guides this process and includes repair proteins and cell...
10.
Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, et al.
PLoS One
. 2010 Sep;
5(9):e12592.
PMID: 20830296
A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types and has been...