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Chad D Walls

Explore the profile of Chad D Walls including associated specialties, affiliations and a list of published articles. Areas
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Articles 11
Citations 298
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Recent Articles
1.
Zhang R, Yu Z, Chen L, Walls C, Zhang S, Wu L, et al.
J Biol Chem . 2020 Mar; 295(18):6187-6201. PMID: 32188694
The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the gene have been linked to many different types of human...
2.
Taylor P, Weinblatt M, Burmester G, Rooney T, Witt S, Walls C, et al.
Arthritis Rheumatol . 2019 Jan; 71(7):1042-1055. PMID: 30663869
Objective: To assess the frequency of cardiovascular and venous thromboembolic events in clinical studies of baricitinib, an oral, selective JAK1 and JAK2 inhibitor approved in more than 50 countries for...
3.
Yu Z, Zhang R, Walls C, Chen L, Zhang S, Wu L, et al.
Biochemistry . 2014 Jun; 53(25):4136-51. PMID: 24935154
The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 2 (SHP2) is a critical signal transducer downstream of growth factors that promotes the activation of the RAS-ERK1/2 cascade. In its...
4.
Walls C, Iliuk A, Bai Y, Wang M, Tao W, Zhang Z
Mol Cell Proteomics . 2013 Sep; 12(12):3759-77. PMID: 24030100
Phosphatase of regenerating liver 3 (PRL3) is suspected to be a causative factor toward cellular metastasis when in excess. To date, the molecular basis for PRL3 function remains an enigma,...
5.
Dumaual C, Steere B, Walls C, Wang M, Zhang Z, Randall S
PLoS One . 2013 Sep; 8(9):e72977. PMID: 24019887
Background: The protein tyrosine phosphatase PRL-1 represents a putative oncogene with wide-ranging cellular effects. Overexpression of PRL-1 can promote cell proliferation, survival, migration, invasion, and metastasis, but the underlying mechanisms...
6.
Yu Z, Xu J, Walls C, Chen L, Zhang S, Zhang R, et al.
J Biol Chem . 2013 Mar; 288(15):10472-82. PMID: 23457302
SHP2 is an allosteric phosphatase essential for growth factor-mediated Ras activation. Germ-line mutations in SHP2 cause clinically similar LEOPARD and Noonan syndromes, two of several autosomal-dominant conditions characterized by gain-of-function...
7.
Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, et al.
J Biol Chem . 2011 Oct; 286(49):42316-42324. PMID: 22009749
Phosphatases of the regenerating liver (PRL) play oncogenic roles in cancer development and metastasis. Although previous studies indicate that PRL-1 promotes cell growth and migration by activating both the ERK1/2...
8.
Abdo M, Liu S, Zhou B, Walls C, Wu L, Knapp S, et al.
J Am Chem Soc . 2008 Sep; 130(40):13196-7. PMID: 18781746
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed...
9.
Liang F, Luo Y, Dong Y, Walls C, Liang J, Jiang H, et al.
J Biol Chem . 2008 Feb; 283(16):10339-46. PMID: 18268019
Phosphatase of regenerating liver 3 (PRL3) is up-regulated in cancer metastases. However, little is known of PRL3-mediated cellular signaling pathways. We previously reported that elevated PRL3 expression increases Src kinase...
10.
Gokmen-Polar Y, Escuin D, Walls C, Soule S, Wang Y, Sanders K, et al.
Cancer Res . 2005 Oct; 65(20):9406-14. PMID: 16230404
2-Methoxyestradiol is an estradiol metabolite with significant antiproliferative and antiangiogenic activity independent of estrogen receptor status. To identify a molecular basis for acquired 2-methoxyestradiol resistance, we generated a stable 2-methoxyestradiol-resistant...