Cesar A Speck-Hernandez
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Explore the profile of Cesar A Speck-Hernandez including associated specialties, affiliations and a list of published articles.
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11
Citations
396
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Recent Articles
1.
Ribeiro M, Venturini L, Speck-Hernandez C, Alabarse P, Xavier T, Taira T, et al.
J Biol Chem
. 2023 Oct;
299(12):105379.
PMID: 37871745
Osteoclasts are specialized cells responsible for bone resorption, a highly energy-demanding process. Focus on osteoclast metabolism could be a key for the treatment of osteolytic diseases including osteoporosis. In this...
2.
Wanderley C, Maganin A, Adjafre B, Mendes A, Anibal Silva C, Quadros A, et al.
Cancer Immunol Res
. 2022 Sep;
10(11):1299-1308.
PMID: 36083496
Cytotoxic agents synergize with immune checkpoint inhibitors and improve outcomes for patients with several cancer types. Nonetheless, a parallel increase in the incidence of dose-limiting side effects, such as peripheral...
3.
Duarte M, Mascarenhas R, Assis A, Tanaka P, Speck-Hernandez C, Passos G
Mol Immunol
. 2021 Oct;
140:127-135.
PMID: 34700158
The autoimmune regulator (Aire) gene in medullary thymic epithelial cells (mTECs) encodes the AIRE protein, which interacts with its partners within the nucleus. This "Aire complex" induces stalled RNA Pol...
4.
Oliveira E, Assis A, Speck-Hernandez C, Duarte M, Passos G
Front Immunol
. 2020 Jun;
11:1039.
PMID: 32547551
Aire is a transcriptional controller in medullary thymic epithelial cells (mTECs) modulating a set of peripheral tissue antigens (PTAs) and non-PTA mRNAs as well as miRNAs. Even miRNAs exerting posttranscriptional...
5.
Colon D, Wanderley C, Franchin M, Silva C, Hiroki C, Castanheira F, et al.
Crit Care
. 2019 Apr;
23(1):113.
PMID: 30961634
Background: Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. Methods:...
6.
Wanderley C, Colon D, Luiz J, Oliveira F, Viacava P, Leite C, et al.
Cancer Res
. 2018 Aug;
78(20):5891-5900.
PMID: 30104241
Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell-cycle arrest. Here, we...
7.
Speck-Hernandez C, Assis A, Felicio R, Cotrim-Sousa L, Pezzi N, Lopes G, et al.
Front Immunol
. 2018 Jun;
9:964.
PMID: 29867946
The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which is crucial for the negative selection of autoreactive thymocytes in the thymus. This process represents the...
8.
Passos G, Speck-Hernandez C, Assis A, Mendes-da-Cruz D
Immunology
. 2017 Sep;
153(1):10-20.
PMID: 28871661
Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, and was cloned and sequenced. Its importance goes beyond its abstract link with human autoimmune disease....
9.
Speck-Hernandez C, Ojeda D, Castro-Vega L, Forero D
J Genet
. 2015 Jul;
94(2):305-8.
PMID: 26174679
No abstract available.
10.
Barragan-Martinez C, Speck-Hernandez C, Montoya-Ortiz G, Mantilla R, Anaya J, Rojas-Villarraga A
PLoS One
. 2013 Jan;
7(12):e51506.
PMID: 23284705
Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents...