Organic Solvents As Risk Factor for Autoimmune Diseases: a Systematic Review and Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Jan 4

PMID 23284705

Citations 45

Authors

Carolina Barragan-Martinez

Cesar A Speck-Hernandez

Gladis Montoya-Ortiz

Ruben D Mantilla

Juan-Manuel Anaya

Adriana Rojas-Villarraga

Affiliations

Soon will be listed here.

Abstract

Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs.

Methods And Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value<0.001).

Conclusion: Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.

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References

Juntunen J, Kinnunen E, Koskenvuo M . Multiple sclerosis and occupational exposure to chemicals: a co-twin control study of a nationwide series of twins. Br J Ind Med. 1989; 46(6):417-9. PMC: 1009796. DOI: 10.1136/oem.46.6.417. View

Shoenfeld Y, Agmon-Levin N . 'ASIA' - autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2010; 36(1):4-8. DOI: 10.1016/j.jaut.2010.07.003. View

Cooper G, Gilbert K, Greidinger E, James J, Pfau J, Reinlib L . Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Environ Health Perspect. 2008; 116(6):695-702. PMC: 2430222. DOI: 10.1289/ehp.11092. View

Lundberg I, Alfredsson L, Plato N, Sverdrup B, Klareskog L, Kleinau S . Occupation, occupational exposure to chemicals and rheumatological disease. A register based cohort study. Scand J Rheumatol. 1994; 23(6):305-10. DOI: 10.3109/03009749409099278. View

Anaya J, Corena R, Castiblanco J, Rojas-Villarraga A, Shoenfeld Y . The kaleidoscope of autoimmunity: multiple autoimmune syndromes and familial autoimmunity. Expert Rev Clin Immunol. 2010; 3(4):623-35. DOI: 10.1586/1744666X.3.4.623. View

Sesso R, STOLLEY P, Salgado N, Pereira A, Ramos O . Exposure to hydrocarbons and rapidly progressive glomerulonephritis. Braz J Med Biol Res. 1990; 23(3-4):225-33. View

Povey A, Guppy M, Wood M, Knight C, Black C, Silman A . Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. Arthritis Rheum. 2001; 44(3):662-5. DOI: 10.1002/1529-0131(200103)44:3<662::AID-ANR115>3.0.CO;2-P. View

Koischwitz D, Marsteller H, Lackner K, Brecht G, Brecht T . [Changes in the arteries in the hand and fingers due to vinyl chloride exposure (author's transl)]. Rofo. 1980; 132(1):62-8. DOI: 10.1055/s-2008-1056524. View

Wang G, Wang J, Fan X, Ansari G, Khan M . Protein adducts of malondialdehyde and 4-hydroxynonenal contribute to trichloroethene-mediated autoimmunity via activating Th17 cells: dose- and time-response studies in female MRL+/+ mice. Toxicology. 2011; 292(2-3):113-22. PMC: 3264691. DOI: 10.1016/j.tox.2011.12.001. View

10.

Khan M, Kaphalia B, Prabhakar B, Kanz M, Ansari G . Trichloroethene-induced autoimmune response in female MRL +/+ mice. Toxicol Appl Pharmacol. 1995; 134(1):155-60. DOI: 10.1006/taap.1995.1179. View

11.

Peden-Adams M, EuDaly J, Heesemann L, Smythe J, Miller J, Gilkeson G . Developmental immunotoxicity of trichloroethylene (TCE): studies in B6C3F1 mice. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006; 41(3):249-71. DOI: 10.1080/10934520500455289. View

12.

Palbykin B, Borg J, Caldwell P, Rowles J, Papoutsis A, Romagnolo D . Trichloroethylene induces methylation of the Serca2 promoter in H9c2 cells and embryonic heart. Cardiovasc Toxicol. 2011; 11(3):204-14. DOI: 10.1007/s12012-011-9113-3. View

13.

Diot E, Lesire V, Guilmot J, Metzger M, Pilore R, Rogier S . Systemic sclerosis and occupational risk factors: a case-control study. Occup Environ Med. 2002; 59(8):545-9. PMC: 1740346. DOI: 10.1136/oem.59.8.545. View

14.

Prince M, Ducker S, James O . Case-control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations. Gut. 2010; 59(4):508-12. DOI: 10.1136/gut.2009.184218. View

15.

Cai P, Konig R, Khan M, Kaphalia B, Ansari G . Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Toxicol Appl Pharmacol. 2007; 220(3):278-83. PMC: 1959509. DOI: 10.1016/j.taap.2007.01.020. View

16.

Shoenfeld Y, Selmi C, Zimlichman E, Gershwin M . The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmun. 2008; 31(4):325-30. DOI: 10.1016/j.jaut.2008.08.004. View

17.

Purdie G, Purdie D, Harrison A . Raynaud's phenomenon in medical laboratory workers who work with solvents. J Rheumatol. 2011; 38(9):1940-6. DOI: 10.3899/jrheum.101129. View

18.

Goldman J . Connective tissue disease in people exposed to organic chemical solvents: systemic sclerosis (scleroderma) in dry cleaning plant and aircraft industry workers. J Clin Rheumatol. 2008; 2(4):185-90. View

19.

Jacob S, Hery M, Protois J, Rossert J, Stengel B . Effect of organic solvent exposure on chronic kidney disease progression: the GN-PROGRESS cohort study. J Am Soc Nephrol. 2006; 18(1):274-81. PMC: 4764668. DOI: 10.1681/ASN.2006060652. View

20.

De Roos A, Cooper G, Alavanja M, Sandler D . Rheumatoid arthritis among women in the Agricultural Health Study: risk associated with farming activities and exposures. Ann Epidemiol. 2005; 15(10):762-70. DOI: 10.1016/j.annepidem.2005.08.001. View