Alpha 2.0
Login Register
» Authors » Cenchen Zhan

Cenchen Zhan

Explore the profile of Cenchen Zhan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 181
Followers 0
Related Specialties
Pharmacology
Biochemistry
Chemistry
Top 10 Co-Authors
Madhavi Pai
Torben Neelands
Chang Z Zhu
Wende Niforatos
Greta L Lundgaard
Steve McGaraughty
Michael E Kort
Ivan Milicic
Odile F El-Kouhen
Jun Xu
Published In
Proc Natl Acad Sci U S A
Eur J Pharmacol
Bioorg Med Chem
Br J Pharmacol
J Pain
Affiliations
Soon will be listed here.
Recent Articles
1.
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na1.7/ Nav1.8 blockers for the treatment of pain
Patel M, Peltier H, Matulenko M, Koenig J, Scanio M, Gum R, et al.
Bioorg Med Chem . 2022 Apr; 63:116743. PMID: 35436748
The voltage-gated sodium channel Na1.7 is an attractive target for the treatment of pain based on the high level of target validation with genetic evidence linking Na1.7 to pain in...
2.
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Frost J, Degoey D, Shi L, Gum R, Fricano M, Lundgaard G, et al.
J Med Chem . 2016 Mar; 59(7):3373-91. PMID: 27015369
The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing target for the potential development of new pain drugs. The...
3.
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models
Zhu C, Vortherms T, Zhang M, Xu J, Swensen A, Niforatos W, et al.
J Pain . 2013 Dec; 15(4):387.e1-14. PMID: 24374196
Unlabelled: Voltage-gated Ca(2+) channels play an important role in nociceptive transmission. There is significant evidence supporting a role for N-, T- and P/Q-type Ca(2+) channels in chronic pain. Here, we...
4.
Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain
Cowart M, Hsieh G, Black L, Zhan C, Gomez E, Pai M, et al.
Eur J Pharmacol . 2012 Apr; 684(1-3):87-94. PMID: 22504024
Histamine H(3) receptor antagonists have been widely reported to improve performance in preclinical models of cognition, but more recently efficacy in pain models has also been described. Here, A-960656 ((R)-2-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-yl)pyridazin-3(2H)-one)...
5.
A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats
Scott V, Vortherms T, Niforatos W, Swensen A, Neelands T, Milicic I, et al.
Biochem Pharmacol . 2011 Dec; 83(3):406-18. PMID: 22153861
Blockade of voltage-gated Ca²⁺ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca²⁺ channel blockers that produce significant antinociception...
6.
Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Hsieh G, Pai M, Chandran P, Hooker B, Zhu C, Salyers A, et al.
Br J Pharmacol . 2010 Oct; 162(2):428-40. PMID: 20880025
Background And Purpose: Cannabinoid CB₂ receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB₂-mediated analgesic...
7.
The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy
Schulke N, Varlamova O, Donovan G, Ma D, Gardner J, Morrissey D, et al.
Proc Natl Acad Sci U S A . 2003 Oct; 100(22):12590-5. PMID: 14583590
Prostate-specific membrane antigen (PSMA) is a type 2 integral membrane glycoprotein that serves as an attractive target for cancer immunotherapy by virtue of its abundant and restricted expression on the...