Cecilia R Chambers
Overview
Explore the profile of Cecilia R Chambers including associated specialties, affiliations and a list of published articles.
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10
Citations
278
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Recent Articles
1.
Chambers C, Watakul S, Schofield P, Howell A, Zhu J, Tran A, et al.
Sci Adv
. 2025 Mar;
11(11):eadq4416.
PMID: 40073121
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known...
2.
Pereira B, Ritchie S, Chambers C, Gordon K, Magenau A, Murphy K, et al.
Sci Adv
. 2024 Jul;
10(27):eadl1197.
PMID: 38959305
Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic...
3.
Uceda-Castro R, Margarido A, Song J, de Gooijer M, Messal H, Chambers C, et al.
Sci Adv
. 2023 Oct;
9(42):eabp9530.
PMID: 37851804
Although initially successful, treatments with chemotherapy often fail because of the recurrence of chemoresistant metastases. Since these tumors develop after treatment, resistance is generally thought to occur in response to...
4.
Chitty J, Yam M, Perryman L, Parker A, Skhinas J, Setargew Y, et al.
Nat Cancer
. 2023 Aug;
4(9):1326-1344.
PMID: 37640930
The lysyl oxidase family represents a promising target in stromal targeting of solid tumors due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its known...
5.
Murphy K, Reed D, Chambers C, Zhu J, Magenau A, Pereira B, et al.
Bio Protoc
. 2023 Jan;
12(24).
PMID: 36618089
The extracellular matrix (ECM) is a non-cellular network of macromolecules, which provides cells and tissues with structural support and biomechanical feedback to regulate cellular function, tissue tension, and homeostasis. Even...
6.
Murphy K, Reed D, Vennin C, Conway J, Nobis M, Yin J, et al.
Sci Adv
. 2021 Sep;
7(40):eabh0363.
PMID: 34586840
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic, chemoresistant malignancy and is characterized by a dense, desmoplastic stroma that modulates PDAC progression. Here, we visualized transient manipulation of focal adhesion...
7.
Murphy K, Chambers C, Herrmann D, Timpson P, Pereira B
Cancers (Basel)
. 2021 Jul;
13(14).
PMID: 34298706
Many cancer studies now recognize that disease initiation, progression, and response to treatment are strongly influenced by the microenvironmental niche. Widespread desmoplasia, or fibrosis, is fundamental to pancreatic cancer development,...
8.
Chambers C, Ritchie S, Pereira B, Timpson P
Mol Oncol
. 2021 Jun;
15(12):3242-3255.
PMID: 34137158
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of...
9.
Pereira B, Vennin C, Papanicolaou M, Chambers C, Herrmann D, Morton J, et al.
Trends Cancer
. 2019 Nov;
5(11):724-741.
PMID: 31735290
Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several protumourigenic functions. Several studies have recently reported that CAFs are...
10.
Mohanty B, Hanson-Manful P, Finn T, Chambers C, McKellar J, Macindoe I, et al.
Proteins
. 2019 Apr;
87(8):699-705.
PMID: 30958578
InterPro family IPR020489 comprises ~1000 uncharacterized bacterial proteins. Previously we showed that overexpressing the Escherichia coli representative of this family, EcYejG, conferred low-level resistance to aminoglycoside antibiotics. In an attempt...