Cecilia P C Chiu
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Explore the profile of Cecilia P C Chiu including associated specialties, affiliations and a list of published articles.
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10
Citations
208
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Recent Articles
1.
Shi R, Dillon M, Compton P, Sawyer W, Thorup J, Kwong M, et al.
Anal Chem
. 2023 Nov;
95(47):17263-17272.
PMID: 37956201
Intact protein mass spectrometry (MS) coupled with liquid chromatography was applied to characterize the pharmacokinetics and stability profiles of therapeutic proteins. However, limitations from chromatography, including throughput and carryover, result...
2.
Chavarria-Smith J, Chiu C, Jackman J, Yin J, Zhang J, Hackney J, et al.
Sci Transl Med
. 2022 Dec;
14(675):eabp9159.
PMID: 36516271
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous...
3.
Jackman J, Stockwell A, Choy D, Xie M, Lu P, Jia G, et al.
J Allergy Clin Immunol
. 2022 Apr;
150(4):972-978.e7.
PMID: 35487308
Background: Clinical studies of type 2 (T2) cytokine-related neutralizing antibodies in asthma have identified a substantial subset of patients with low levels of T2 inflammation who do not benefit from...
4.
Wang P, Sun L, Clark R, Hristopoulos M, Chiu C, Dillon M, et al.
Mol Cancer Ther
. 2022 Apr;
21(6):974-985.
PMID: 35364611
New therapeutics and combination regimens have led to marked clinical improvements for the treatment of a subset of colorectal cancer. Immune checkpoint inhibitors have shown clinical efficacy in patients with...
5.
Baruch A, Luca D, Kahn R, Cowan K, Leabman M, Budha N, et al.
Clin Cardiol
. 2017 Mar;
40(7):503-511.
PMID: 28326559
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low-density lipoprotein (LDL) receptors, thereby leading to a rise in circulating LDL cholesterol (LDL-C). RG7652 is a fully human monoclonal antibody against...
6.
Lin L, Rakic B, Chiu C, Lameignere E, Wakarchuk W, Withers S, et al.
J Biol Chem
. 2011 Sep;
286(43):37237-48.
PMID: 21880735
The first x-ray crystallographic structure of a CAZY family-52 glycosyltransferase, that of the membrane associated α2,3/α2,6 lipooligosaccharide sialyltransferase from Neisseria meningitidis serotype L1 (NST), has been solved to 1.95 Å...
7.
Chiu C, Lairson L, Gilbert M, Wakarchuk W, Withers S, Strynadka N
Biochemistry
. 2007 May;
46(24):7196-204.
PMID: 17518445
Sialic acid is an essential sugar in biology that plays key roles in numerous cellular processes and interactions. The biosynthesis of sialylated glycoconjugates is catalyzed by five distinct families of...
8.
Aharoni A, Thieme K, Chiu C, Buchini S, Lairson L, Chen H, et al.
Nat Methods
. 2006 Jul;
3(8):609-14.
PMID: 16862135
Engineering of glycosyltransferases (GTs) with desired substrate specificity for the synthesis of new oligosaccharides holds great potential for the development of the field of glycobiology. However, engineering of GTs by...
9.
Lairson L, Chiu C, Ly H, He S, Wakarchuk W, Strynadka N, et al.
J Biol Chem
. 2004 Apr;
279(27):28339-44.
PMID: 15075344
Lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 alpha-1,4-galactosyltransferase from Neisseria meningitidis, catalyzes the transfer of galactose from UDP galactose to terminal lactose-containing acceptor sugars with net retention of anomeric configuration....
10.
Chiu C, Watts A, Lairson L, Gilbert M, Lim D, Wakarchuk W, et al.
Nat Struct Mol Biol
. 2004 Jan;
11(2):163-70.
PMID: 14730352
Sialic acid terminates oligosaccharide chains on mammalian and microbial cell surfaces, playing critical roles in recognition and adherence. The enzymes that transfer the sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc)...