Cecile Debacker
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Explore the profile of Cecile Debacker including associated specialties, affiliations and a list of published articles.
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9
Citations
177
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Recent Articles
1.
Jungnickel K, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, et al.
Nat Cell Biol
. 2024 Jun;
26(7):1047-1061.
PMID: 38839979
The lysosomal degradation of macromolecules produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here we deorphanized the major facilitator superfamily domain containing 1 (MFSD1) protein,...
2.
Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(32).
PMID: 34344826
Lysosomes degrade excess or damaged cellular components and recycle their building blocks through membrane transporters. They also act as nutrient-sensing signaling hubs to coordinate cell responses. The membrane protein PQ-loop...
3.
Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini P, et al.
J Med Chem
. 2020 Jul;
63(15):8231-8249.
PMID: 32608236
Sialin, encoded by the gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of exogenous sialic acids, leading to...
4.
Jezegou A, Llinares E, Anne C, Kieffer-Jaquinod S, ORegan S, Aupetit J, et al.
Proc Natl Acad Sci U S A
. 2012 Nov;
109(50):E3434-43.
PMID: 23169667
Cystinosin, the lysosomal cystine exporter defective in cystinosis, is the founding member of a family of heptahelical membrane proteins related to bacteriorhodopsin and characterized by a duplicated motif termed the...
5.
Pietrancosta N, Anne C, Prescher H, Ruivo R, Sagne C, Debacker C, et al.
J Biol Chem
. 2012 Feb;
287(14):11489-97.
PMID: 22334707
Secondary active transporters from the SLC17 protein family are required for excitatory and purinergic synaptic transmission, sialic acid metabolism, and renal function, and several members are associated with inherited neurological...
6.
Ruivo R, Carlo Bellenchi G, Chen X, Zifarelli G, Sagne C, Debacker C, et al.
Proc Natl Acad Sci U S A
. 2012 Jan;
109(5):E210-7.
PMID: 22232659
Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs "uphill" across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual eukaryotic,...
7.
Savalas L, Gasnier B, Damme M, Lubke T, Wrocklage C, Debacker C, et al.
Biochem J
. 2011 Jun;
439(1):113-28.
PMID: 21692750
DIRC2 (Disrupted in renal carcinoma 2) has been initially identified as a breakpoint-spanning gene in a chromosomal translocation putatively associated with the development of renal cancer. The DIRC2 protein belongs...
8.
Ruivo R, Sharifi A, Boubekeur S, Morin P, Anne C, Debacker C, et al.
Biol Cell
. 2008 Apr;
100(9):551-9.
PMID: 18399798
Background Information: Free sialic acid storage diseases are caused by mutations of a lysosomal sialic acid transporter called sialin. We showed recently that the milder clinical form, Salla disease, and...
9.
Kertesz N, Samson J, Debacker C, Wu H
Gene
. 2002 Sep;
294(1-2):13-24.
PMID: 12234663
We previously isolated, from the earliest population of CD34+ hematopoietic progenitors that form in the aorta of the human embryo, a partial DNA complementary to RNA (cDNA) sequence that was...