Cecelia I Pearson
Overview
Explore the profile of Cecelia I Pearson including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
223
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0
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Recent Articles
1.
Ackerman S, Pearson C, Gregorio J, Gonzalez J, Kenkel J, Hartmann F, et al.
Nat Cancer
. 2022 Feb;
2(1):18-33.
PMID: 35121890
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after systemic...
2.
Natsoulis G, Pearson C, Gollub J, P Eynon B, Ferng J, Nair R, et al.
Mol Syst Biol
. 2008 Mar;
4:175.
PMID: 18364709
We have used a supervised classification approach to systematically mine a large microarray database derived from livers of compound-treated rats. Thirty-four distinct signatures (classifiers) for pharmacological and toxicological end points...
3.
Tugendreich S, Pearson C, Sagartz J, Jarnagin K, Kolaja K
Toxicol Pathol
. 2006 Apr;
34(2):168-79.
PMID: 16642600
Toxicogenomics using a reference database can provide a better understanding and prediction of toxicity, largely by creating biomarkers that tie gene expression to actual pathology events. During the course of...
4.
Ganter B, Tugendreich S, Pearson C, Ayanoglu E, Baumhueter S, Bostian K, et al.
J Biotechnol
. 2005 Jul;
119(3):219-44.
PMID: 16005536
Successful drug discovery requires accurate decision making in order to advance the best candidates from initial lead identification to final approval. Chemogenomics, the use of genomic tools in pharmacology and...
5.
Natsoulis G, El Ghaoui L, R G Lanckriet G, Tolley A, Leroy F, Dunlea S, et al.
Genome Res
. 2005 May;
15(5):724-36.
PMID: 15867433
A large gene expression database has been produced that characterizes the gene expression and physiological effects of hundreds of approved and withdrawn drugs, toxicants, and biochemical standards in various organs...