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Catrina C Fronick

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Articles 37
Citations 2980
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Recent Articles
1.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
Nat Cancer . 2024 Oct; 5(11):1713-1736. PMID: 39478117
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we...
2.
Jacoby M, Duncavage E, Khanna A, Chang G, Nonavinkere Srivatsan S, Miller C, et al.
Leukemia . 2024 Oct; 39(1):166-177. PMID: 39367170
Accurate assessment of therapy response in myelodysplastic neoplasm (MDS) has been challenging. Directly monitoring mutational disease burden may be useful, but is not currently included in MDS response criteria, and...
3.
Foltz S, Li Y, Yao L, Terekhanova N, Weerasinghe A, Gao Q, et al.
bioRxiv . 2024 Aug; PMID: 39149342
Somatic mutation phasing informs our understanding of cancer-related events, like driver mutations. We generated linked-read whole genome sequencing data for 23 samples across disease stages from 14 multiple myeloma (MM)...
4.
Ramirez C, Becker-Hapak M, Singhal K, Russler-Germain D, Frenkel F, Barnell E, et al.
Blood Adv . 2024 May; 8(15):4035-4049. PMID: 38713894
Personalized cancer vaccines designed to target neoantigens represent a promising new treatment paradigm in oncology. In contrast to classical idiotype vaccines, we hypothesized that "polyvalent" vaccines could be engineered for...
5.
Iglesia M, Jayasinghe R, Chen S, Terekhanova N, Herndon J, Storrs E, et al.
bioRxiv . 2023 Nov; PMID: 37961519
Breast cancer is a heterogeneous disease, and treatment is guided by biomarker profiles representing distinct molecular subtypes. Breast cancer arises from the breast ductal epithelium, and experimental data suggests breast...
6.
Gomez F, Fisk B, McMichael J, Mosior M, Foltz J, Skidmore Z, et al.
Cancer Res Commun . 2023 Nov; 3(11):2312-2330. PMID: 37910143
Significance: Our data demonstrate the utility of ultra-deep exome sequencing in uncovering somatic variants in Hodgkin lymphoma, creating new opportunities to define the genes that are recurrently mutated in this...
7.
Abel H, Oetjen K, Miller C, Ramakrishnan S, Day R, Helton N, et al.
Blood Adv . 2023 Jun; 7(16):4586-4598. PMID: 37339484
TP53-mutated myeloid malignancies are associated with complex cytogenetics and extensive structural variants, which complicates detailed genomic analysis by conventional clinical techniques. We performed whole-genome sequencing (WGS) of 42 acute myeloid...
8.
Abel H, Oetjen K, Miller C, Ramakrishnan S, Day R, Helton N, et al.
medRxiv . 2023 Jan; PMID: 36711871
Key Points: WGS comprehensively determines mutation status, resulting in the reclassification of 12% of cases from mono-allelic to multi-hit Chromothripsis is more frequent than previously appreciated, with a preference for...
9.
Zhou D, Jayasinghe R, Chen S, Herndon J, Iglesia M, Navale P, et al.
Nat Genet . 2022 Aug; 54(9):1390-1405. PMID: 35995947
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA...
10.
Petti A, Williams S, Miller C, Fiddes I, Srivatsan S, Chen D, et al.
Nat Commun . 2022 Jul; 13(1):4216. PMID: 35864110
No abstract available.