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Catrina C Fronick

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Recent Articles
11.
Menssen A, Khanna A, Miller C, Nonavinkere Srivatsan S, Chang G, Shao J, et al.
Blood Cancer Discov . 2022 Jun; 3(4):330-345. PMID: 35709710
Significance: Subclone expansion is a hallmark of progression from MDS to secondary AML. Subclonal signaling gene mutations are common at MDS (often at low levels), show complex and convergent patterns...
12.
Kodgule R, Chen J, Khonde P, Robinson J, DAlbora A, Cook L, et al.
Blood Adv . 2022 Apr; 6(23):6051-6055. PMID: 35395066
No abstract available.
13.
Petti A, Khan S, Xu Z, Helton N, Fronick C, Fulton R, et al.
Blood Cancer Discov . 2022 Jan; 3(1):32-49. PMID: 35019859
To better understand clonal and transcriptional adaptations after relapse in patients with acute myeloid leukemia (AML), we collected presentation and relapse samples from six normal karyotype AML cases. We performed...
14.
Ferraro F, Miller C, Christensen K, Helton N, OLaughlin M, Fronick C, et al.
Proc Natl Acad Sci U S A . 2021 Nov; 118(49). PMID: 34845035
Acute myeloid leukemia (AML) patients rarely have long first remissions (LFRs; >5 y) after standard-of-care chemotherapy, unless classified as favorable risk at presentation. Identification of the mechanisms responsible for long...
15.
Brioschi S, Wang W, Peng V, Wang M, Shchukina I, Greenberg Z, et al.
Science . 2021 Jun; 373(6553). PMID: 34083450
The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging,...
16.
Liu R, Gao Q, Foltz S, Fowles J, Yao L, Wang J, et al.
Nat Commun . 2021 May; 12(1):2559. PMID: 33963182
Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. Despite recent treatment advances, it is still incurable as disease progression is not fully understood. To investigate MM...
17.
Lalli M, Langmade J, Chen X, Fronick C, Sawyer C, Burcea L, et al.
Clin Chem . 2020 Oct; 67(2):415-424. PMID: 33098427
Background: Rapid, reliable, and widespread testing is required to curtail the ongoing COVID-19 pandemic. Current gold-standard nucleic acid tests are hampered by supply shortages in critical reagents including nasal swabs,...
18.
Dang H, Krasnick B, White B, Grossman J, Strand M, Zhang J, et al.
Sci Adv . 2020 Jun; 6(24):eaay9691. PMID: 32577507
Tumor heterogeneity and evolution drive treatment resistance in metastatic colorectal cancer (mCRC). Patient-derived xenografts (PDXs) can model mCRC biology; however, their ability to accurately mimic human tumor heterogeneity is unclear....
19.
Lalli M, Langmade S, Chen X, Fronick C, Sawyer C, Burcea L, et al.
medRxiv . 2020 Jun; PMID: 32511508
Rapid, reliable, and widespread testing is required to curtail the ongoing COVID-19 pandemic. Current gold standard nucleic acid tests are hampered by supply shortages in critical reagents including nasal swabs,...
20.
Petti A, Williams S, Miller C, Fiddes I, Srivatsan S, Chen D, et al.
Nat Commun . 2019 Aug; 10(1):3660. PMID: 31413257
Virtually all tumors are genetically heterogeneous, containing mutationally-defined subclonal cell populations that often have distinct phenotypes. Single-cell RNA-sequencing has revealed that a variety of tumors are also transcriptionally heterogeneous, but...