Cathy Lester
Overview
Explore the profile of Cathy Lester including associated specialties, affiliations and a list of published articles.
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23
Citations
251
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Recent Articles
1.
Lester C, Byrd E, Shobair M, Yan G
Chem Res Toxicol
. 2023 Jan;
36(2):230-242.
PMID: 36701522
Structure activity relationship (SAR)-based read-across often is an integral part of toxicological safety assessment, and justification of the prediction presents the most challenging aspect of the approach. It has been...
2.
Obringer C, Lester C, Karb M, Smith A, Ellison C
Regul Toxicol Pharmacol
. 2022 Dec;
137:105315.
PMID: 36494001
Fatty esters of 2-ethylhexanoic acid (EHA) and 2-ethylhexanol (EH) are commonly used in cosmetics. Human liver and skin S9 and human plasma were used to determine the in vitro rates...
3.
Allemang A, Lester C, Roth T, Pfuhler S, Peuschel H, Kosemund K, et al.
Food Chem Toxicol
. 2022 Jul;
168:113290.
PMID: 35863484
The detection of 2-chloroethanol in foods generally follows an assumption that the pesticide ethylene oxide has been used at some stage in the supply chain. In this situation the Pesticide...
4.
Ouedraogo G, Alexander-White C, Bury D, Clewell 3rd H, Cronin M, Cull T, et al.
Regul Toxicol Pharmacol
. 2022 May;
132:105161.
PMID: 35508214
Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with...
5.
Bury D, Alexander-White C, Clewell 3rd H, Cronin M, Desprez B, Detroyer A, et al.
Regul Toxicol Pharmacol
. 2021 Apr;
123:104931.
PMID: 33905778
This case study on the model substance caffeine demonstrates the viability of a 10-step read-across (RAX) framework in practice. New approach methodologies (NAM), including RAX and physiologically-based kinetic (PBK) modelling...
6.
Obringer C, Wu S, Troutman J, Karb M, Lester C
Regul Toxicol Pharmacol
. 2021 Mar;
122:104918.
PMID: 33741472
Parabens are antimicrobial compounds used as preservatives in cosmetics, foods, and pharmaceuticals. Paraben exposure occurs through a variety of routes including dermal absorption, ingestion, and inhalation. Ester bond hydrolysis has...
7.
Lester C, Hewitt N, Muller-Vieira U, Mayer M, Ellison C, Duplan H, et al.
Toxicol In Vitro
. 2020 Nov;
72:105051.
PMID: 33188879
Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the impact of chain structure on skin and liver metabolism. Incubations with...
8.
Hewitt N, Gregoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, et al.
J Appl Toxicol
. 2019 Dec;
40(3):403-415.
PMID: 31867769
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic-relevant chemicals. The penetration of finite doses (10 μL/cm ) of chemicals was...
9.
Lester C, Troutman J, Obringer C, Wehmeyer K, Stoffolano P, Karb M, et al.
Food Chem Toxicol
. 2019 May;
131:110523.
PMID: 31129256
1,2-Unsaturated pyrrolizidine alkaloids (PAs) are sometimes present in foods or herbal supplements/medicines as impurities and pose potential concerns for liver genotoxicity/carcinogenicity. PAs display a strong structure toxicity relationship, however, current...
10.
Allemang A, Mahony C, Lester C, Pfuhler S
Food Chem Toxicol
. 2018 Aug;
121:72-81.
PMID: 30125636
Plant-based 1,2-unsaturated Pyrrolizidine Alkaloids (PAs) can be found as contaminants in foods like teas, herbs and honey. PAs are responsible for liver genotoxicity/carcinogenicity following metabolic activation, making them a relevant...