Michael Karb
Overview
Explore the profile of Michael Karb including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
15
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Recent Articles
1.
Wu S, Ellison C, Naciff J, Karb M, Obringer C, Yan G, et al.
Toxicol Sci
. 2022 Dec;
191(2):343-356.
PMID: 36583546
The purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data, and physiologically based pharmacokinetic (PBPK) models to support read-across for a series of...
2.
Obringer C, Lester C, Karb M, Smith A, Ellison C
Regul Toxicol Pharmacol
. 2022 Dec;
137:105315.
PMID: 36494001
Fatty esters of 2-ethylhexanoic acid (EHA) and 2-ethylhexanol (EH) are commonly used in cosmetics. Human liver and skin S9 and human plasma were used to determine the in vitro rates...
3.
Zoller A, Wehmeyer K, Krivos K, Karb M, Stoffolano P, Nash J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2021 Apr;
1173:122614.
PMID: 33819797
Pyrithione glucuronide (PTG) and 2-thiopyridine glucuronide (ThPG) have been reported to be the major urinary metabolites in multiple animal species following administration of zinc pyrithione (ZnPT). However, the formation of...
4.
Obringer C, Wu S, Troutman J, Karb M, Lester C
Regul Toxicol Pharmacol
. 2021 Mar;
122:104918.
PMID: 33741472
Parabens are antimicrobial compounds used as preservatives in cosmetics, foods, and pharmaceuticals. Paraben exposure occurs through a variety of routes including dermal absorption, ingestion, and inhalation. Ester bond hydrolysis has...
5.
Lester C, Troutman J, Obringer C, Wehmeyer K, Stoffolano P, Karb M, et al.
Food Chem Toxicol
. 2019 May;
131:110523.
PMID: 31129256
1,2-Unsaturated pyrrolizidine alkaloids (PAs) are sometimes present in foods or herbal supplements/medicines as impurities and pose potential concerns for liver genotoxicity/carcinogenicity. PAs display a strong structure toxicity relationship, however, current...