Cathal Seoighe
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Explore the profile of Cathal Seoighe including associated specialties, affiliations and a list of published articles.
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88
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4028
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Recent Articles
1.
Anthony H, Seoighe C
Brief Bioinform
. 2024 Aug;
25(5).
PMID: 39129364
Microsatellite instability (MSI) is a phenomenon seen in several cancer types, which can be used as a biomarker to help guide immune checkpoint inhibitor treatment. To facilitate this, researchers have...
2.
Zhong Y, Seoighe C, Yang H
Bioinform Adv
. 2024 May;
4(1):vbae009.
PMID: 38736682
Motivation: Post-market unexpected Adverse Drug Reactions (ADRs) are associated with significant costs, in both financial burden and human health. Due to the high cost and time required to run clinical...
3.
Rosean S, Sosa E, OShea D, Raj S, Seoighe C, Greally J
BMC Bioinformatics
. 2024 May;
25(1):179.
PMID: 38714913
Background: As genomic studies continue to implicate non-coding sequences in disease, testing the roles of these variants requires insights into the cell type(s) in which they are likely to be...
4.
Sosa E, Rosean S, OShea D, Raj S, Seoighe C, Greally J
bioRxiv
. 2023 Oct;
PMID: 37905111
Motivation: To understand whether sets of genomic loci are enriched at the regulatory loci of one or more cell types, we developed the gaiaAssociation package to perform Regulatory Landscape Enrichment...
5.
OSullivan B, Seoighe C
NAR Cancer
. 2023 Sep;
5(3):zcad051.
PMID: 37746635
Accurate identification of somatic mutations and allele frequencies in cancer has critical research and clinical applications. Several computational tools have been developed for this purpose but, in the absence of...
6.
Nembaware V, Bennett D, Chimusa E, Chikowore T, Daodu R, Bitoungui V, et al.
Trends Genet
. 2023 Sep;
39(11):803-807.
PMID: 37714735
To accelerate the impact of African genomics on human health, data science skills and awareness of Africa's rich genetic diversity must be strengthened globally. We describe the first African genomics...
7.
Staunton P, Peters A, Seoighe C
Genetics
. 2023 Jul;
225(2).
PMID: 37450609
Variation in the rates and characteristics of germline and somatic mutations across the genome of an organism is informative about DNA damage and repair processes and can also shed light...
8.
Makrooni M, OShea D, Geeleher P, Seoighe C
PLoS Comput Biol
. 2022 Oct;
18(10):e1010278.
PMID: 36197939
Gene set analysis (GSA) remains a common step in genome-scale studies because it can reveal insights that are not apparent from results obtained for individual genes. Many different computational tools...
9.
Makrooni M, OSullivan B, Seoighe C
BMC Cancer
. 2022 Aug;
22(1):840.
PMID: 35918650
Background: Tumour mutation burden (TMB), defined as the number of somatic mutations per megabase within the sequenced region in the tumour sample, has been used as a biomarker for predicting...
10.
Bennett D, OShea D, Ferguson J, Morris D, Seoighe C
Sci Rep
. 2021 Oct;
11(1):19571.
PMID: 34599249
Ongoing increases in the size of human genotype and phenotype collections offer the promise of improved understanding of the genetics of complex diseases. In addition to the biological insights that...