Catarina Grandela
Overview
Explore the profile of Catarina Grandela including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
552
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0
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Recent Articles
1.
Bois A, Grandela C, Gallant J, Mummery C, Menasche P
NPJ Regen Med
. 2025 Jan;
10(1):6.
PMID: 39843488
Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart,...
2.
Blanch-Asensio A, Grandela C, Mummery C, Davis R
Nat Protoc
. 2024 Aug;
PMID: 39179886
Targeted integration of large DNA cargoes (>10 kb) or genomic replacements in mammalian cells, such as human pluripotent stem cells (hPS cells), remains challenging. Here we describe a platform termed...
3.
Blanch-Asensio A, Grandela C, Brandao K, de Korte T, Mei H, Ariyurek Y, et al.
Cell Rep Methods
. 2022 Oct;
2(10):100300.
PMID: 36313798
Inserting large DNA payloads (>10 kb) into specific genomic sites of mammalian cells remains challenging. Applications ranging from synthetic biology to evaluating the pathogenicity of disease-associated variants for precision medicine...
4.
Brandao K, Grandela C, Yiangou L, Mummery C, Davis R
Methods Mol Biol
. 2021 Mar;
2454:531-557.
PMID: 33755904
Advances in genome editing and our ability to derive and differentiate human induced pluripotent stem cells (hiPSCs) into a wide variety of cell types present in the body is revolutionizing...
5.
Brandao K, van den Brink L, Miller D, Grandela C, van Meer B, Mol M, et al.
Stem Cell Reports
. 2020 Nov;
15(5):1127-1139.
PMID: 33176122
Mutations in KCNH2 can lead to long QT syndrome type 2. Variable disease manifestation observed with this channelopathy is associated with the location and type of mutation within the protein,...
6.
van den Brink L, Brandao K, Yiangou L, Mol M, Grandela C, Mummery C, et al.
Stem Cell Res
. 2020 Jan;
43:101698.
PMID: 31945612
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a powerful platform for in vitro modelling of cardiac diseases, safety pharmacology and drug screening. All these applications require large...
7.
van den Brink L, Grandela C, Mummery C, Davis R
Stem Cells
. 2019 Oct;
38(2):174-186.
PMID: 31664757
Research on mechanisms underlying monogenic cardiac diseases such as primary arrhythmias and cardiomyopathies has until recently been hampered by inherent limitations of heterologous cell systems, where mutant genes are expressed...
8.
Sala L, van Meer B, Tertoolen L, Bakkers J, Bellin M, Davis R, et al.
Circ Res
. 2017 Dec;
122(3):e5-e16.
PMID: 29282212
Rationale: There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used in single experimental models....
9.
Kemper K, Rodermond H, Colak S, Grandela C, Medema J
Apoptosis
. 2012 Jan;
17(5):528-37.
PMID: 22223359
Colorectal cancer stem cells (CSCs) drive tumor growth and are suggested to initiate distant metastases. Moreover, colon CSCs are reportedly more resistant to conventional chemotherapy, which is in part due...
10.
Tra T, Gong L, Kao L, Li X, Grandela C, Devenish R, et al.
PLoS One
. 2011 Nov;
6(11):e27485.
PMID: 22110659
Autophagy (macroautophagy) is a degradative process that involves the sequestration of cytosolic material including organelles into double membrane vesicles termed autophagosomes for delivery to the lysosome. Autophagy is essential for...