Revitalizing the Heart: Strategies and Tools for Cardiomyocyte Regeneration Post-myocardial Infarction

Overview

Journal NPJ Regen Med

Date 2025 Jan 22

PMID 39843488

Authors

Axelle Bois

Catarina Grandela

James Gallant

Christine Mummery

Philippe Menasche

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This review explores strategies for heart regeneration, offers insights into cardiomyocyte proliferation, evaluates in vivo models, and discusses integrating in vitro human cardiac models to advance cardiac regeneration research.

Citing Articles

Two promising approaches in the treatment of myocardial infarction: stem cells and gene therapy.

Gao S, Li D, Wang B, Zhang H, Chen L Front Cardiovasc Med. 2025; 12:1540066.

PMID: 40046966 PMC: 11880279. DOI: 10.3389/fcvm.2025.1540066.

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