Cassandra N Spracklen
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Explore the profile of Cassandra N Spracklen including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Daniele C, Farland L, Park K, Schnatz P, Shadyab A, Stefanick M, et al.
Early Hum Dev
. 2023 Aug;
184:105839.
PMID: 37549575
Background: Advancements in medical technology and pharmacologic interventions have drastically improved survival of infants born preterm and low birth weight, but knowledge regarding the long-term health impacts of these individuals...
12.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2023 May;
618(7965):E19-E20.
PMID: 37237109
No abstract available.
13.
Holman-Vittone A, Monahan B, LeBlanc E, Liu S, Nassir R, Saquib N, et al.
J Dev Orig Health Dis
. 2023 Apr;
14(3):333-340.
PMID: 37114530
Preterm birth has been associated with insulin resistance and beta-cell dysfunction, a hallmark characteristic of type 2 diabetes. However, studies investigating the relationship between a personal history of being born...
14.
Suzuki K, Hatzikotoulas K, Southam L, Taylor H, Yin X, Lorenz K, et al.
medRxiv
. 2023 Apr;
PMID: 37034649
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study...
15.
Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, et al.
Genome Biol
. 2022 Dec;
23(1):268.
PMID: 36575460
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of...
16.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, et al.
Nature
. 2022 Oct;
610(7933):704-712.
PMID: 36224396
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using...
17.
Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, et al.
Am J Hum Genet
. 2022 Aug;
109(8):1366-1387.
PMID: 35931049
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from...
18.
Winkler T, Rasheed H, Teumer A, Gorski M, Rowan B, Stanzick K, et al.
Commun Biol
. 2022 Jun;
5(1):580.
PMID: 35697829
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses...
19.
Mahajan A, Spracklen C, Zhang W, Ng M, Petty L, Kitajima H, et al.
Nat Genet
. 2022 May;
54(5):560-572.
PMID: 35551307
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis...
20.
Loh M, Zhang W, Ng H, Schmid K, Lamri A, Tong L, et al.
Commun Biol
. 2022 May;
5(1):441.
PMID: 35513483
No abstract available.