Cassandra N Spracklen
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Explore the profile of Cassandra N Spracklen including associated specialties, affiliations and a list of published articles.
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59
Citations
3333
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Recent Articles
1.
Bandesh K, Motakis E, Nargund S, Kursawe R, Selvam V, Bhuiyan R, et al.
bioRxiv
. 2025 Feb;
PMID: 39896672
Pancreatic islets maintain glucose homeostasis through coordinated action of their constituent endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding of...
2.
Drzymalla E, Raffield L, Kolor K, Koyama A, Moonesinghe R, Pavkov M, et al.
Diabetes Care
. 2025 Jan;
48(2):212-219.
PMID: 39841967
Objective: The goal of this study was to assess the additive value of considering type 2 diabetes (T2D) polygenic risk score (PRS) in addition to family history for T2D prediction....
3.
Tiwari V, Jin B, Sun O, Lopez Gonzalez E, Chen M, Wu X, et al.
bioRxiv
. 2025 Jan;
PMID: 39763913
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD do...
4.
Associations of Combined Genetic and Lifestyle Risks with Incident Type 2 Diabetes in the UK Biobank
Zhao C, Hatzikotoulas K, Balasubramanian R, Bertone-Johnson E, Cai N, Huang L, et al.
medRxiv
. 2025 Jan;
PMID: 39763538
Background: Type 2 diabetes (T2D) results from a complex interplay between genetic predisposition and lifestyle factors. Both genetic susceptibility and unhealthy lifestyle are known to be associated with elevated T2D...
5.
Sokolowski E, Kursawe R, Selvam V, Bhuiyan R, Thibodeau A, Zhao C, et al.
Cell Metab
. 2024 Oct;
36(11):2468-2488.e7.
PMID: 39383866
Endoplasmic reticulum (ER) and inflammatory stress responses contribute to islet dysfunction in type 2 diabetes (T2D). Comprehensive genomic understanding of these human islet stress responses and whether T2D-associated genetic variants...
6.
Daniele C, Wacks R, Farland L, Manson J, Qi L, Shadyab A, et al.
BMC Womens Health
. 2024 Oct;
24(1):546.
PMID: 39363289
Background: Women who reach menarche and menopause at earlier ages have been shown to be at increased risk for numerous conditions including cardiovascular disease, cancer, depression, and obesity; however, risk...
7.
Mandla R, Lorenz K, Yin X, Bocher O, Huerta-Chagoya A, Arruda A, et al.
medRxiv
. 2024 Jul;
PMID: 39072045
Discerning the mechanisms driving type 2 diabetes (T2D) pathophysiology from genome-wide association studies (GWAS) remains a challenge. To this end, we integrated omics information from 16 multi-tissue and multi-ancestry expression,...
8.
Suzuki K, Hatzikotoulas K, Southam L, Taylor H, Yin X, Lorenz K, et al.
Nature
. 2024 Feb;
627(8003):347-357.
PMID: 38374256
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution...
9.
Rahalkar N, Holman-Vittone A, Daniele C, Wacks R, Gagnon A, DAgata A, et al.
J Dev Orig Health Dis
. 2023 Oct;
14(5):623-630.
PMID: 37886824
An individual's birthweight, a marker of exposures, was recently associated with certain psychiatric conditions. However, studies investigating the relationship between an individual's preterm birth status and/or birthweight and risk for...
10.
Sarsani V, Brotman S, Xianyong Y, Fernandes Silva L, Laakso M, Spracklen C
HGG Adv
. 2023 Oct;
5(1):100252.
PMID: 37859345
Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 diabetes and obesity, identified >20 associated loci. However, most loci were identified in populations of European...