Casey E Sheehy
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Explore the profile of Casey E Sheehy including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
40
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0
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Recent Articles
1.
Heger L, Schommer N, Van Bruggen S, Sheehy C, Chan W, Wagner D
Sci Rep
. 2024 Jun;
14(1):14524.
PMID: 38914598
NLRP3 inflammasome has been implicated in neutrophil polarization and extrusion of neutrophil extracellular traps (NETs) in vitro and facilitates secretion of Il1-beta (IL-1β). Permanent ligation of the left anterior descending...
2.
Van Bruggen S, Sheehy C, Kraisin S, Frederix L, Wagner D, Martinod K
J Thromb Haemost
. 2024 Feb;
22(5):1496-1509.
PMID: 38325598
Background: Obesity is an increasing problem in our current society and is expected to keep rising in incidence. With its multiorigin, complex pathophysiology, it is difficult to treat and easy...
3.
NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient
Van Bruggen S, Jarrot P, Thomas E, Sheehy C, Silva C, Hsu A, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(35):e2303814120.
PMID: 37603754
Neutrophil recruitment to sites of infection and inflammation is an essential process in the early innate immune response. Upon activation, a subset of neutrophils rapidly assembles the multiprotein complex known...
4.
Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis
Heger L, Schommer N, Fukui S, Van Bruggen S, Sheehy C, Chu L, et al.
Life Sci Alliance
. 2023 Jul;
6(10).
PMID: 37500179
Rheumatoid arthritis is a prototypic inflammatory condition with affected patients being at greater risk of incident heart failure (HF). Targeting innate immune cell function in the pathogenesis of HF bears...
5.
Gajendran C, Fukui S, Sadhu N, Zainuddin M, Rajagopal S, Gosu R, et al.
Sci Rep
. 2023 Feb;
13(1):3189.
PMID: 36823444
Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies...
6.
Fukui S, Fukui S, Van Bruggen S, Shi L, Sheehy C, Chu L, et al.
Sci Rep
. 2022 Dec;
12(1):21313.
PMID: 36494392
NLR family pyrin domain containing 3 (NLRP3) inflammasome mediates caspase-1-dependent processing of inflammatory cytokines such as IL-1β, an essential endothelial activator, and contributes to the pathology of inflammatory diseases. To...
7.
Fukui S, Gutch S, Fukui S, Cherpokova D, Aymonnier K, Sheehy C, et al.
Arthritis Rheumatol
. 2022 Feb;
74(7):1139-1146.
PMID: 35166055
Objective: Genome-wide association studies have connected PADI4, encoding peptidylarginine deiminase 4 (PAD4), with rheumatoid arthritis (RA). PAD4 promotes neutrophil extracellular trap (NET) formation. This study was undertaken to investigate the...
8.
Tsiros D, Sheehy C, Pecchia S, Nugent M
J Biol Chem
. 2019 Oct;
294(46):17603-17611.
PMID: 31601651
Vascular endothelial growth factor-A (VEGF) plays a critical role in stimulating angiogenesis in normal and disease states. Anti-VEGF antibodies have been developed to manage pathological angiogenesis. Bevacizumab, sold under the...