Carson S Hartlage
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Explore the profile of Carson S Hartlage including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
127
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Recent Articles
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Haase S, Banerjee K, Mujeeb A, Hartlage C, Nunez F, Nunez F, et al.
J Clin Invest
. 2022 Sep;
132(22).
PMID: 36125896
Pediatric high-grade gliomas (pHGGs) are the leading cause of cancer-related deaths in children in the USA. Sixteen percent of hemispheric pediatric and young adult HGGs encode Gly34Arg/Val substitutions in the...
3.
Lerch A, Ten Bosch Q, LAzou Jackson M, Bettis A, Bernuzzi M, Murphy G, et al.
BMC Med
. 2022 Jun;
20(1):202.
PMID: 35705986
Background: Despite large outbreaks in humans seeming improbable for a number of zoonotic pathogens, several pose a concern due to their epidemiological characteristics and evolutionary potential. To enable effective responses...
4.
Alghamri M, McClellan B, Avvari R, Thalla R, Carney S, Hartlage C, et al.
Sci Adv
. 2021 Sep;
7(40):eabh3243.
PMID: 34586841
Mutant isocitrate-dehydrogenase 1 () synthesizes the oncometabolite 2-hydroxyglutarate (2HG), which elicits epigenetic reprogramming of the glioma cells’ transcriptome by inhibiting DNA and histone demethylases. We show that the efficacy of...
5.
Alghamri M, McClellan B, Hartlage C, Haase S, Faisal S, Thalla R, et al.
Front Pharmacol
. 2021 Jun;
12:680021.
PMID: 34084145
Gliomas are one of the most lethal types of cancers accounting for ∼80% of all central nervous system (CNS) primary malignancies. Among gliomas, glioblastomas (GBM) are the most aggressive, characterized...