Carolyn E Machamer
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Explore the profile of Carolyn E Machamer including associated specialties, affiliations and a list of published articles.
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49
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1774
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Recent Articles
1.
Del Rosario O, Suresh K, Kallem M, Singh G, Shah A, Zheng L, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Mar;
324(5):L700-L711.
PMID: 36976920
We have previously identified mitogen-activated protein kinase-activated protein kinase 2 (MK2) is required for caspase-3 nuclear translocation in the execution of apoptosis; however, little is known of the underlying mechanisms....
2.
Suresh K, Del Rosario O, Kallem M, Singh G, Shah A, Zheng L, et al.
Physiol Genomics
. 2023 Mar;
55(4):168-178.
PMID: 36878491
Non-small cell lung cancers (NSCLCs) demonstrate intrinsic resistance to cell death, even after chemotherapy. Previous work suggested defective nuclear translocation of active caspase-3 in observed resistance to cell death. We...
3.
Casciola-Rosen L, Thiemann D, Andrade F, Trejo-Zambrano M, Leonard E, Spangler J, et al.
JCI Insight
. 2022 Mar;
7(9).
PMID: 35349483
BackgroundSome clinical features of severe COVID-19 represent blood vessel damage induced by activation of host immune responses initiated by the coronavirus SARS-CoV-2. We hypothesized autoantibodies against angiotensin-converting enzyme 2 (ACE2),...
4.
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
Esquejo R, Roqueta-Rivera M, Shao W, Phelan P, Seneviratne U, Am Ende C, et al.
Cell Chem Biol
. 2020 Oct;
28(2):169-179.e7.
PMID: 33096051
Sterol regulatory element-binding proteins (SREBPs) are master transcriptional regulators of the mevalonate pathway and lipid metabolism and represent an attractive therapeutic target for lipid metabolic disorders. SREBPs are maintained in...
5.
Casciola-Rosen L, Thiemann D, Andrade F, Trejo Zambrano M, Hooper J, Leonard E, et al.
medRxiv
. 2020 Oct;
PMID: 33083808
SARS-CoV-2 infection induces severe disease in a subpopulation of patients, but the underlying mechanisms remain unclear. We demonstrate robust IgM autoantibodies that recognize angiotensin converting enzyme-2 (ACE2) in 18/66 (27%)...
6.
Suresh K, Carino K, Johnston L, Servinsky L, Machamer C, Kolb T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2019 Mar;
316(6):L1118-L1126.
PMID: 30908935
Noncanonical roles for caspase-3 are emerging in the fields of cancer and developmental biology. However, little is known of nonapoptotic functions of caspase-3 in most cell types. We have recently...
7.
Westerbeck J, Machamer C
J Virol
. 2019 Mar;
93(11).
PMID: 30867314
Coronaviruses (CoVs) assemble by budding into the lumen of the early Golgi complex prior to exocytosis. The small CoV envelope (E) protein plays roles in assembly, virion release, and pathogenesis....
8.
Sisk J, Frieman M, Machamer C
J Gen Virol
. 2018 Mar;
99(5):619-630.
PMID: 29557770
Enveloped viruses gain entry into host cells by fusing with cellular membranes, a step that is required for virus replication. Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle...
9.
Gilbert C, Sztul E, Machamer C
Mol Biol Cell
. 2018 Feb;
29(8):937-947.
PMID: 29467256
Cold temperature blocks used to synchronize protein trafficking inhibit GBF1 function, leading to a decrease in ARF1-GTP levels and mislocalization of the ARF1 effector golgin-160. Several other, but not all,...
10.
Shao W, Machamer C, Espenshade P
J Lipid Res
. 2016 Jun;
57(8):1564-73.
PMID: 27324795
Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of cellular lipid homeostasis and activate expression of genes required for fatty acid, triglyceride, and cholesterol synthesis and uptake. SREBP...