Caroline C Sigman
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Explore the profile of Caroline C Sigman including associated specialties, affiliations and a list of published articles.
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32
Citations
1351
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Recent Articles
1.
Sweeney S, Hamadeh H, Abrams N, Adam S, Brenner S, Connors D, et al.
Cancer Res
. 2023 Jan;
83(8):1183-1190.
PMID: 36625851
The analysis of big healthcare data has enormous potential as a tool for advancing oncology drug development and patient treatment, particularly in the context of precision medicine. However, there are...
2.
Sweeney S, Hamadeh H, Abrams N, Adam S, Brenner S, Connors D, et al.
Cancer Res
. 2023 Jan;
83(8):1175-1182.
PMID: 36625843
Big data in healthcare can enable unprecedented understanding of diseases and their treatment, particularly in oncology. These data may include electronic health records, medical imaging, genomic sequencing, payor records, and...
3.
Anderson K, Auclair D, Adam S, Agarwal A, Anderson M, Avet-Loiseau H, et al.
Clin Cancer Res
. 2021 Jul;
27(19):5195-5212.
PMID: 34321279
The development of novel agents has transformed the treatment paradigm for multiple myeloma, with minimal residual disease (MRD) negativity now achievable across the entire disease spectrum. Bone marrow-based technologies to...
4.
Keating S, Taylor D, Plant A, David Litwack E, Kuhn P, Greenspan E, et al.
Clin Transl Sci
. 2018 Mar;
11(3):267-276.
PMID: 29498218
The high-content interrogation of single cells with platforms optimized for the multiparameter characterization of cells in liquid and solid biopsy samples can enable characterization of heterogeneous populations of cells ex...
5.
Keeney M, Wood B, Hedley B, DiGiuseppe J, Stetler-Stevenson M, Paietta E, et al.
Cytometry B Clin Cytom
. 2017 May;
94(2):239-249.
PMID: 28475275
Background: Minimal residual disease (MRD) in B lymphoblastic leukemia (B-ALL) by flow cytometry is an established prognostic factor used to adjust treatment in most pediatric therapeutic protocols. MRD in B-ALL...
6.
Anderson K, Auclair D, Kelloff G, Sigman C, Avet-Loiseau H, Farrell A, et al.
Clin Cancer Res
. 2017 Apr;
23(15):3980-3993.
PMID: 28428191
Treatment of myeloma has benefited from the introduction of more effective and better tolerated agents, improvements in supportive care, better understanding of disease biology, revision of diagnostic criteria, and new...
7.
Kelloff G, Sigman C, Scher H
Urol Oncol
. 2015 Mar;
33(6):295-301.
PMID: 25746942
Background: The Food and Drug Administration (FDA) has called for the use of analytically validated biomarkers that have strong evidence of being fit for purpose to identify patients likely to...
8.
Herbst R, Gandara D, Hirsch F, Redman M, LeBlanc M, Mack P, et al.
Clin Cancer Res
. 2015 Feb;
21(7):1514-24.
PMID: 25680375
The Lung Master Protocol (Lung-MAP, S1400) is a groundbreaking clinical trial designed to advance the efficient development of targeted therapies for squamous cell carcinoma (SCC) of the lung. There are...
9.
Parkinson D, McCormack R, Keating S, Gutman S, Hamilton S, Mansfield E, et al.
Clin Cancer Res
. 2014 Mar;
20(6):1428-44.
PMID: 24634466
This article defines and describes best practices for the academic and business community to generate evidence of clinical utility for cancer molecular diagnostic assays. Beyond analytical and clinical validation, successful...
10.
Parkinson D, Dracopoli N, Petty B, Compton C, Cristofanilli M, Deisseroth A, et al.
J Transl Med
. 2012 Jul;
10:138.
PMID: 22747748
This manuscript summarizes current thinking on the value and promise of evolving circulating tumor cell (CTC) technologies for cancer patient diagnosis, prognosis, and response to therapy, as well as accelerating...