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Caroline C Friedel

Explore the profile of Caroline C Friedel including associated specialties, affiliations and a list of published articles. Areas
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Articles 75
Citations 3109
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Recent Articles
1.
Ohnezeit D, Huang J, Westerkamp U, Brinschwitz V, Schmidt C, Gunther T, et al.
PLoS Pathog . 2024 Aug; 20(8):e1012426. PMID: 39110744
Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT)...
2.
Wang Z, Himanen S, Haikala H, Friedel C, Vihervaara A, Barboric M
Nucleic Acids Res . 2023 Oct; 51(20):10970-10991. PMID: 37811895
P-TEFb and CDK12 facilitate transcriptional elongation by RNA polymerase II. Given the prominence of both kinases in cancer, gaining a better understanding of their interplay could inform the design of...
3.
Djakovic L, Hennig T, Reinisch K, Milic A, Whisnant A, Wolf K, et al.
Nat Commun . 2023 Jul; 14(1):4591. PMID: 37524699
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is...
4.
Weiss E, Friedel C
Bioinform Adv . 2023 Jul; 3(1):vbad085. PMID: 37456509
Motivation: To date, no methods are available for the targeted identification of genomic subregions with differences in sequencing read distributions between two conditions. Existing approaches either only determine absolute read...
5.
Schwanke H, Magalhaes V, Schmelz S, Wyler E, Hennig T, Gunther T, et al.
J Virol . 2023 Jun; 97(6):e0040023. PMID: 37289084
Induction of type I interferon (IFN) gene expression is among the first lines of cellular defense a virus encounters during primary infection. We previously identified the tegument protein M35 of...
6.
Lodha M, Muchsin I, Jurges C, Juranic Lisnic V, LHernault A, Rutkowski A, et al.
PLoS Pathog . 2023 May; 19(5):e1010992. PMID: 37172056
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor...
7.
Weiss E, Hennig T, Grassl P, Djakovic L, Whisnant A, Jurges C, et al.
J Virol . 2023 Apr; 97(5):e0038123. PMID: 37093003
Herpes simplex virus 1 (HSV-1) infection exerts a profound shutoff of host gene expression at multiple levels. Recently, HSV-1 infection was reported to also impact promoter-proximal RNA polymerase II (Pol...
8.
Wang Z, Macakova M, Bugai A, Kuznetsov S, Hassinen A, Lenasi T, et al.
Nucleic Acids Res . 2023 Feb; 51(4):1687-1706. PMID: 36727434
Positive transcription elongation factor b (P-TEFb) is the crucial player in RNA polymerase II (Pol II) pause release that has emerged as a promising target in cancer. Because single-agent therapy...
9.
Friedel C
Methods Mol Biol . 2022 Dec; 2610:31-48. PMID: 36534279
Functional genomics techniques based on next-generation sequencing provide new avenues for studying host responses to viral infections at multiple levels, including transcriptional and translational processes and chromatin organization. This chapter...
10.
Friedl M, Djakovic L, Kluge M, Hennig T, Whisnant A, Backes S, et al.
PLoS One . 2022 Oct; 17(10):e0276467. PMID: 36279270
The herpes simplex virus 1 (HSV-1) virion host shut-off (vhs) protein cleaves both cellular and viral mRNAs by a translation-initiation-dependent mechanism, which should spare circular RNAs (circRNAs). Here, we show...