Carolina R Melo-Silva
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Explore the profile of Carolina R Melo-Silva including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
104
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Recent Articles
1.
Melo-Silva C, Sigal L
Cell Mol Immunol
. 2024 Jun;
21(9):999-1007.
PMID: 38918577
The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics. LNs are...
2.
Montoya B, Melo-Silva C, Tang L, Kafle S, Lidskiy P, Bajusz C, et al.
Mol Ther
. 2024 Apr;
32(6):1790-1804.
PMID: 38605519
The role of CD8 T cells in SARS-CoV-2 pathogenesis or mRNA-LNP vaccine-induced protection from lethal COVID-19 is unclear. Using mouse-adapted SARS-CoV-2 virus (MA30) in C57BL/6 mice, we show that CD8...
3.
Melo-Silva C, Knudson C, Tang L, Kafle S, Springer L, Choi J, et al.
Cells
. 2023 May;
12(9).
PMID: 37174743
Genetically modified (GM) mice are essential tools in biomedical research. Traditional methods for generating GM mice are expensive and require specialized personnel and equipment. The use of clustered regularly interspaced...
4.
Qin J, Jeon J, Xu J, Langston L, Marasini R, Mou S, et al.
Front Immunol
. 2023 Apr;
14:1126392.
PMID: 37033973
Because of the rapid mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an effective vaccine against SARS-CoV-2 variants is needed to prevent coronavirus disease 2019 (COVID-19). T cells, in...
5.
Montoya B, Knudson C, Melo-Silva C, Tang L, Kafle S, Sigal L
J Virol
. 2023 Jan;
97(2):e0194522.
PMID: 36651749
Receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL) are proteins that are critical for necroptosis, a mechanism of programmed cell death that is both activated when...
6.
Melo-Silva C, Roman M, Knudson C, Tang L, Xu R, Tassetto M, et al.
Cell Rep
. 2022 Nov;
41(8):111676.
PMID: 36417857
Inflammatory monocytes (iMOs) and B cells are the main targets of the poxvirus ectromelia virus (ECTV) in the lymph nodes of mice and play distinct roles in surviving the infection....
7.
Knudson C, Ferez M, Alves-Peixoto P, Erkes D, Melo-Silva C, Tang L, et al.
J Virol
. 2021 Jul;
95(19):e0056621.
PMID: 34260270
Cytotoxic CD4 T lymphocytes (CD4-CTL) are important in antiviral immunity. For example, we have previously shown that in mice, CD4-CTL are important to control ectromelia virus (ECTV) infection. How viral...
8.
Rasouli J, Casella G, Ishikawa L, Thome R, Boehm A, Ertel A, et al.
Front Immunol
. 2021 Jun;
12:679498.
PMID: 34149716
IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have...
9.
Melo-Silva C, Alves-Peixoto P, Heath N, Tang L, Montoya B, Knudson C, et al.
PLoS Pathog
. 2021 May;
17(5):e1009593.
PMID: 34015056
Type I interferons (IFN-I) are antiviral cytokines that signal through the ubiquitous IFN-I receptor (IFNAR). Following footpad infection with ectromelia virus (ECTV), a mouse-specific pathogen, C57BL/6 (B6) mice survive without...
10.
Stotesbury C, Wong E, Tang L, Montoya B, Knudson C, Melo-Silva C, et al.
Aging Cell
. 2020 Jul;
19(7):e13170.
PMID: 32657004
It is known that aging decreases natural resistance to viral diseases due to dysfunctional innate and adaptive immune responses, but the nature of these dysfunctions, particularly in regard to innate...