Carolina D Garciarena
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Explore the profile of Carolina D Garciarena including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
395
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Recent Articles
1.
McHale T, Garciarena C, Fagan R, Smith S, Martin-Loches I, Curley G, et al.
Crit Care Med
. 2018 May;
46(8):e805-e810.
PMID: 29782355
Objectives: The vascular endothelium is a major target of sepsis-induced events, and endothelial activation accounts for much of the pathology of sepsis. Urinary tract infections and pneumonia caused by Escherichia...
2.
Ryan A, Kearney C, Shen N, Khan U, Kelly A, Probst C, et al.
Adv Mater
. 2018 Mar;
30(15):e1706442.
PMID: 29504165
Electroconductive substrates are emerging as promising functional materials for biomedical applications. Here, the development of biohybrids of collagen and pristine graphene that effectively harness both the biofunctionality of the protein...
3.
Garciarena C, Malik A, Swietach P, Moreno A, Vaughan-Jones R
FASEB J
. 2017 Nov;
32(4):1969-1981.
PMID: 29183963
Most mammalian cells can intercommunicate via connexin-assembled, gap-junctional channels. To regulate signal transmission, connexin (Cx) channel permeability must respond dynamically to physiological and pathophysiological stimuli. One key stimulus is intracellular...
4.
Garciarena C, McHale T, Martin-Loeches I, Kerrigan S
Crit Care
. 2017 Sep;
21(1):246.
PMID: 28946901
No abstract available.
5.
Ryan A, Brougham C, Garciarena C, Kerrigan S, OBrien F
Drug Discov Today
. 2016 Apr;
21(9):1437-1445.
PMID: 27117348
The field of tissue engineering is developing biomimetic biomaterial scaffolds that are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them...
6.
Garciarena C, McHale T, Watkin R, Kerrigan S
Pathogens
. 2015 Dec;
4(4):869-82.
PMID: 26690226
Staphylococcus aureus is an opportunistic pathogen often carried asymptomatically on the human body. Upon entry to the otherwise sterile environment of the cardiovascular system, S. aureus can lead to serious...
7.
Garciarena C, Youm J, Swietach P, Vaughan-Jones R
J Mol Cell Cardiol
. 2013 Apr;
61:51-9.
PMID: 23602948
Acid extrusion on Na(+)-coupled pH-regulatory proteins (pH-transporters), Na(+)/H(+) exchange (NHE1) and Na(+)-HCO3(-) co-transport (NBC), drives Na(+) influx into the ventricular myocyte. This H(+)-activated Na(+)-influx is acutely up-regulated at pHi<7.2, greatly...
8.
Garciarena C, Ma Y, Swietach P, Huc L, Vaughan-Jones R
J Physiol
. 2013 Feb;
591(9):2287-306.
PMID: 23420656
Membrane acid extrusion by Na(+)/H(+) exchange (NHE1) and Na(+)-HCO3(-) co-transport (NBC) is essential for maintaining a low cytoplasmic [H(+)] (∼60 nm, equivalent to an intracellular pH (pHi) of 7.2). This...
9.
Garciarena C, Fantinelli J, Caldiz C, Chiappe de Cingolani G, Ennis I, Perez N, et al.
Cell Physiol Biochem
. 2011 Feb;
27(1):13-22.
PMID: 21325817
Background/aims: Flow restoration to ischemic myocardium reduces infarct size (IS), but it also promotes reperfusion injury. A burst of reactive oxygen species (ROS) and/or NHE-1 reactivation were proposed to explain...
10.
Diaz R, Nolly M, Massarutti C, Casarini M, Garciarena C, Ennis I, et al.
Cell Physiol Biochem
. 2010 Nov;
26(4-5):531-40.
PMID: 21063091
Background/aims: This study aimed to identify the signaling pathway for the proposed link between phosphodiesterase-5A (PDE5A) inhibition and decreased cardiac Na(+)/H(+) exchanger (NHE-1) activity. Methods: NHE-1 activity was assessed in...