Nestor G Perez
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Explore the profile of Nestor G Perez including associated specialties, affiliations and a list of published articles.
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41
Citations
468
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Recent Articles
1.
Escudero D, Fantinelli J, Martinez V, Arbelaez L, Amarillo M, Perez N, et al.
Eur J Clin Invest
. 2024 Jan;
54(5):e14172.
PMID: 38293760
Background: Glucocorticoid (GR) and mineralocorticoid (MR) receptors are highly expressed in cardiac tissue, and both can be activated by corticosteroids. MR activation, in acute myocardial infarction (AMI), worsens cardiac function,...
2.
Zavala M, Diaz R, Villa-Abrille M, Perez N
Front Cardiovasc Med
. 2021 Mar;
8:622583.
PMID: 33718450
The stretch of cardiac muscle increases developed force in two phases. The first phase occurs immediately after stretch and is the expression of the Frank-Starling mechanism, while the second one...
3.
Escudero D, Perez N, Diaz R
Front Cardiovasc Med
. 2021 Mar;
8:617519.
PMID: 33693035
The cardiac Na/H exchanger (NHE1) is a membrane glycoprotein fundamental for proper cell functioning due its multiple housekeeping tasks, including regulation of intracellular pH, Na concentration, and cell volume. In...
4.
Escudero D, Brea M, Caldiz C, Amarillo M, Aranda J, Portiansky E, et al.
Eur J Pharmacol
. 2020 Nov;
891:173724.
PMID: 33152335
Previously, we have shown that an increased cGMP-activated protein Kinase (PKG) activity after phosphodiesterase 5 (PDE5) inhibition by Sildenafil (SIL), leads to myocardial Na/H exchanger (NHE1) inhibition preserving its basal...
5.
Brea M, Diaz R, Escudero D, Zavala M, Portiansky E, Villa-Abrille M, et al.
Biochem Pharmacol
. 2019 Oct;
170:113667.
PMID: 31622577
Pathological cardiac hypertrophy (PCH) can be triggered by epidermal growth factor receptor (EGFR) transactivation. Progression of PCH can be prevented by inhibition of hyperactive Na/H exchanger isoform 1 (NHE1). We...
6.
Zavala M, Diaz R, Medina A, Acosta M, Escudero D, Ennis I, et al.
Cell Physiol Biochem
. 2019 Mar;
52(2):172-185.
PMID: 30816666
Background/aims: Myocardial stretch increases cardiac force in two consecutive phases: The first one due to Frank-Starling mechanism, followed by the gradually developed slow force response (SFR). The latter is the...
7.
Diaz R, Escudero D, Brea M, Morgan P, Perez N
Eur J Pharmacol
. 2019 Feb;
849:96-105.
PMID: 30721701
Since the original description as potent antianginal compounds, phosphodiesterase 5A inhibitors have continuously increased their possible therapeutic applications. In the heart, Sildenafil was shown to protect against an ischemic insult...
8.
Ciocci Pardo A, Diaz R, Arbelaez L, Perez N, Swenson E, Mosca S, et al.
J Appl Physiol (1985)
. 2018 Jan;
125(2):340-352.
PMID: 29357509
During ischemia, increased anaerobic glycolysis results in intracellular acidosis. Activation of alkalinizing transport mechanisms associated with carbonic anhydrases (CAs) leads to myocardial intracellular Ca increase. We characterize the effects of...
9.
Brea M, Diaz R, Escudero D, Caldiz C, Portiansky E, Morgan P, et al.
J Am Heart Assoc
. 2016 Oct;
5(10).
PMID: 27744404
Background: Myocardial stretch increases force biphasically: the Frank-Starling mechanism followed by the slow force response (SFR). Based on pharmacological strategies, we proposed that epidermal growth factor (EGF) receptor (EGFR or...
10.
Vargas L, Pinilla O, Diaz R, Sepulveda D, Swenson E, Perez N, et al.
Cardiovasc Pathol
. 2016 Sep;
25(6):468-477.
PMID: 27614168
Background: Two potent carbonic anhydrase (CA) inhibitors with widely differing membrane permeability, poorly diffusible benzolamide (BZ), and highly diffusible ethoxzolamide (ETZ) were assessed to determine whether they can reduce cardiac...