Carol Buettger
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Explore the profile of Carol Buettger including associated specialties, affiliations and a list of published articles.
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12
Citations
443
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Recent Articles
1.
Zelent B, Odili S, Buettger C, Zelent D, Chen P, Fenner D, et al.
Biochem J
. 2011 Aug;
440(2):203-15.
PMID: 21831042
GK (glucokinase) is activated by glucose binding to its substrate site, is inhibited by GKRP (GK regulatory protein) and stimulated by GKAs (GK activator drugs). To explore further the mechanisms...
2.
Cuesta-Munoz A, Tuomi T, Cobo-Vuilleumier N, Koskela H, Odili S, Stride A, et al.
Diabetes Care
. 2009 Nov;
33(2):290-2.
PMID: 19903754
Objective: To evaluate the heterogeneity in the clinical expression in a family with glucokinase mature-onset diabetes of the young (GCK-MODY). Research Design And Methods: Members (three generations) of the same...
3.
Sayed S, Langdon D, Odili S, Chen P, Buettger C, Schiffman A, et al.
Diabetes
. 2009 Apr;
58(6):1419-27.
PMID: 19336674
Objective: Heterozygous activating mutations of glucokinase have been reported to cause hypoglycemia attributable to hyperinsulinism in a limited number of families. We report three children with de novo glucokinase hyperinsulinism...
4.
Li C, Nissim I, Chen P, Buettger C, Najafi H, Daikhin Y, et al.
J Biol Chem
. 2008 May;
283(25):17238-49.
PMID: 18445600
Pancreatic beta cells are hyper-responsive to amino acids but have decreased glucose sensitivity after deletion of the sulfonylurea receptor 1 (SUR1) both in man and mouse. It was hypothesized that...
5.
Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, et al.
Biochem J
. 2008 Mar;
413(2):269-80.
PMID: 18370929
Tryptophan fluorescence was used to study GK (glucokinase), an enzyme that plays a prominent role in glucose homoeostasis which, when inactivated or activated by mutations, causes diabetes mellitus or hypoglycaemia...
6.
Zelent D, Golson M, Koeberlein B, Quintens R, Van Lommel L, Buettger C, et al.
Diabetes
. 2006 Jun;
55(7):1923-9.
PMID: 16804059
Enzymatic activity of glucokinase was demonstrated, quantitated, and characterized kinetically in rat and mouse pituitary extracts using a highly specific and sensitive spectrometric assay. A previously proposed hypothesis that the...
7.
Sagen J, Odili S, Bjorkhaug L, Zelent D, Buettger C, Kwagh J, et al.
Diabetes
. 2006 May;
55(6):1713-22.
PMID: 16731834
Glucokinase functions as a glucose sensor in pancreatic beta-cells and regulates hepatic glucose metabolism. A total of 83 probands were referred for a diagnostic screening of mutations in the glucokinase...
8.
Gloyn A, Odili S, Zelent D, Buettger C, Castleden H, Steele A, et al.
J Biol Chem
. 2005 Jan;
280(14):14105-13.
PMID: 15677479
Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied the GCK V62M mutation identified in two families and...
9.
Li C, Buettger C, Kwagh J, Matter A, Daikhin Y, Nissim I, et al.
J Biol Chem
. 2004 Jan;
279(14):13393-401.
PMID: 14736887
Children with hypoglycemia due to recessive loss of function mutations of the beta-cell ATP-sensitive potassium (K(ATP)) channel can develop hypoglycemia in response to protein feeding. We hypothesized that amino acids...
10.
Gloyn A, Noordam K, Willemsen M, Ellard S, Lam W, Campbell I, et al.
Diabetes
. 2003 Aug;
52(9):2433-40.
PMID: 12941786
Glucokinase (GCK) is a key regulatory enzyme in the pancreatic beta-cell and catalyzes the rate-limiting step for beta-cell glucose metabolism. We report two novel GCK mutations (T65I and W99R) that...