Carol Babij
Overview
Explore the profile of Carol Babij including associated specialties, affiliations and a list of published articles.
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5
Citations
117
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Recent Articles
1.
Liu L, Lee M, Kim J, Whittington D, Bregman H, Hua Z, et al.
Bioorg Med Chem
. 2016 May;
24(13):3093.
PMID: 27234892
No abstract available.
2.
Liu L, Lee M, Kim J, Whittington D, Bregman H, Hua Z, et al.
Bioorg Med Chem
. 2016 Apr;
24(10):2215-34.
PMID: 27085672
One of the challenges for targeting B-Raf(V600E) with small molecule inhibitors had been achieving adequate selectivity over the wild-type protein B-Raf(WT), as inhibition of the latter has been associated with...
3.
Babij C, Zhang Y, Kurzeja R, Munzli A, Shehabeldin A, Fernando M, et al.
Cancer Res
. 2011 Jul;
71(17):5818-26.
PMID: 21742770
Despite the prevalence of KRAS mutations in human cancers, there remain no targeted therapies for treatment. The serine-threonine kinase STK33 has been proposed to be required for the survival of...
4.
Carnahan J, Beltran P, Babij C, Le Q, Rose M, Vonderfecht S, et al.
Mol Cancer Ther
. 2010 Jul;
9(8):2399-410.
PMID: 20663930
Raf inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent activating mutations in B-Raf. Here, we show that cell lines and tumors harboring mutant B-Raf were...
5.
Smith A, DeMorin F, Paras N, Huang Q, Petkus J, Doherty E, et al.
J Med Chem
. 2009 Sep;
52(20):6189-92.
PMID: 19764794
The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked pyridylpyrimidine benzamide 2 was identified...