Carlos M Opazo
Overview
Explore the profile of Carlos M Opazo including associated specialties, affiliations and a list of published articles.
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15
Citations
408
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Recent Articles
1.
Uzungil V, Luza S, Opazo C, Mees I, Li S, Ang C, et al.
Neuropharmacology
. 2024 Jan;
246:109837.
PMID: 38184274
Background: Current antidepressants have limitations due to insufficient efficacy and delay before improvement in symptoms. Polymorphisms of the serotonin transporter (5-HTT) gene have been linked to depression (when combined with...
2.
Lotan A, Luza S, Opazo C, Ayton S, Lane D, Mancuso S, et al.
Mol Psychiatry
. 2023 Feb;
28(5):2058-2070.
PMID: 36750734
Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for schizophrenia do not target disruptions in late maturational reshaping...
3.
Ravanfar P, Syeda W, Jayaram M, Rushmore R, Moffat B, Lin A, et al.
Schizophrenia (Heidelb)
. 2022 Oct;
8(1):86.
PMID: 36289238
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in...
4.
Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression
Uzungil V, Tran H, Aitken C, Wilson C, Opazo C, Li S, et al.
Neurotherapeutics
. 2022 Jul;
19(5):1662-1685.
PMID: 35861925
Depressed individuals who carry the short allele for the serotonin-transporter-linked promotor region of the gene are more vulnerable to stress and have reduced response to first-line antidepressants such as selective...
5.
Ravanfar P, Loi S, Syeda W, Van Rheenen T, Bush A, Desmond P, et al.
Front Neurosci
. 2021 Mar;
15:618435.
PMID: 33679303
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging technique, quantitative susceptibility mapping (QSM), has enabled for...
6.
Luza S, Opazo C, Bousman C, Pantelis C, Bush A, Everall I
Lancet Psychiatry
. 2020 Feb;
7(6):528-537.
PMID: 32061320
The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis, synaptogenesis, and neurotransmission by determining the localisation, interaction, and...
7.
Acevedo K, Masaldan S, Opazo C, Bush A
J Biol Inorg Chem
. 2019 Oct;
24(8):1141-1157.
PMID: 31650248
Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain function, including neurotransmitter synthesis and release, neurotransmission, and protein...
8.
Meiklejohn H, Mostaid M, Luza S, Mancuso S, Kang D, Atherton S, et al.
J Psychiatr Res
. 2019 Mar;
113:51-57.
PMID: 30901725
A number of recent studies have suggested the ubiquitin proteasome system (UPS) in schizophrenia is dysfunctional. The purpose of this study was to investigate UBE2K, a ubiquitin-conjugating (E2) enzyme within...
9.
Bousman C, Luza S, Mancuso S, Kang D, Opazo C, Mostaid M, et al.
Sci Rep
. 2019 Feb;
9(1):2307.
PMID: 30783160
Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free...
10.
Gallegos S, Pacheco C, Peters C, Opazo C, Aguayo L
Front Neurosci
. 2015 Mar;
9:59.
PMID: 25805964
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which...