Carlos M Opazo
Overview
Explore the profile of Carlos M Opazo including associated specialties, affiliations and a list of published articles.
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15
Citations
408
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Recent Articles
11.
Pacheco C, Morales C, Ramirez A, Munoz F, Gallegos S, Caviedes P, et al.
J Neurochem
. 2015 Feb;
132(6):731-41.
PMID: 25669123
It has been postulated that the accumulation of extracellular α-synuclein (α-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to alterations in ionic homeostasis. However,...
12.
Castro P, Ramirez A, Sepulveda F, Peters C, Fierro H, Waldron J, et al.
Front Aging Neurosci
. 2014 Dec;
6:319.
PMID: 25520655
Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently increases...
13.
Vicario-Orri E, Opazo C, Munoz F
J Alzheimers Dis
. 2014 Aug;
43(4):1097-113.
PMID: 25147115
Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of axons and axon terminals...
14.
Opazo C, Greenough M, Bush A
Front Aging Neurosci
. 2014 Jul;
6:143.
PMID: 25071552
Copper is critical for the Central Nervous System (CNS) development and function. In particular, different studies have shown the effect of copper at brain synapses, where it inhibits Long Term...
15.
Acevedo K, Opazo C, Norrish D, Challis L, Li Q, White A, et al.
J Biol Chem
. 2014 Mar;
289(16):11007-11019.
PMID: 24610780
Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics through the secretory pathway. We have previously reported that copper promotes a change...