Carlos Alvarez-Navarro
Overview
Explore the profile of Carlos Alvarez-Navarro including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
263
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Recent Articles
1.
Rauseo D, Contreras-Baeza Y, Faurand H, Carcamo N, Suarez R, von Faber-Castell A, et al.
bioRxiv
. 2024 Jul;
PMID: 39071354
We addressed the question of mitochondrial lactate metabolism using genetically-encoded sensors. The organelle was found to contain a dynamic lactate pool that leads to dose- and time-dependent protein lactylation. In...
2.
Sanz-Bravo A, Alvarez-Navarro C, Martin-Esteban A, Barnea E, Admon A, Lopez de Castro J
Mol Cell Proteomics
. 2018 Apr;
17(7):1308-1323.
PMID: 29632046
The Endoplasmic reticulum aminopeptidase I (ERAP1) trims peptides to their optimal size for binding to Major Histocompatibility Complex class I proteins. The natural polymorphism of this enzyme is associated with...
3.
Lopez de Castro J, Alvarez-Navarro C, Brito A, Guasp P, Martin-Esteban A, Sanz-Bravo A
Mol Immunol
. 2016 Aug;
77:193-204.
PMID: 27522479
The inflammatory diseases that are most strongly associated with major histocompatibility Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum aminopeptidase (ERAP) 1 and/or 2, often in epistasis...
4.
Guasp P, Alvarez-Navarro C, Gomez-Molina P, Martin-Esteban A, Marcilla M, Barnea E, et al.
Arthritis Rheumatol
. 2015 Sep;
68(2):505-15.
PMID: 26360328
Objective: To characterize the peptidome of the Behçet's disease-associated HLA-B*51:01 allotype as well as the differential features of major peptide subsets and their distinct endoplasmic reticulum aminopeptidase 1 (ERAP-1)-mediated processing....
5.
Alvarez-Navarro C, Martin-Esteban A, Barnea E, Admon A, Lopez de Castro J
Mol Cell Proteomics
. 2015 Apr;
14(7):1770-80.
PMID: 25892735
Birdshot chorioretinopathy is a rare ocular inflammation whose genetic association with HLA-A*29:02 is the highest between a disease and a major histocompatibility complex (MHC) molecule. It belongs to a group...
6.
Garcia-Medel N, Sanz-Bravo A, Alvarez-Navarro C, Gomez-Molina P, Barnea E, Marcilla M, et al.
Mol Cell Proteomics
. 2014 Sep;
13(12):3367-80.
PMID: 25187574
HLA-B27 is strongly associated with ankylosing spondylitis (AS). We analyzed the relationship between structure, peptide specificity, folding, and stability of the seven major HLA-B27 subtypes to determine the role of...
7.
Alvarez-Navarro C, Lopez de Castro J
Mol Immunol
. 2013 Aug;
57(1):12-21.
PMID: 23916068
The endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with a significant influence in the...
8.
Alvarez-Navarro C, Cragnolini J, Santos H, Barnea E, Admon A, Morreale A, et al.
J Biol Chem
. 2013 Jul;
288(36):25810-25825.
PMID: 23867464
Reactive arthritis (ReA) is an HLA-B27-associated spondyloarthropathy that is triggered by diverse bacteria, including Chlamydia trachomatis, a frequent intracellular parasite. HLA-B27-restricted T-cell responses are elicited against this bacterium in ReA...
9.
Alvarez-Navarro C, Lopez de Castro J
Curr Opin Rheumatol
. 2013 May;
25(4):419-25.
PMID: 23656713
Purpose Of Review: Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an aminopeptidase of the endoplasmic reticulum involved in trimming of peptides to their optimal size for binding to major histocompatibility complex...
10.
Garcia-Medel N, Sanz-Bravo A, Nguyen D, Galocha B, Gomez-Molina P, Martin-Esteban A, et al.
Mol Cell Proteomics
. 2012 Aug;
11(11):1416-29.
PMID: 22918227
The association of ERAP1 with ankylosing spondylitis (AS)1 among HLA-B27-positive individuals suggests that ERAP1 polymorphism may affect pathogenesis by altering peptide-dependent features of the HLA-B27 molecule. Comparisons of HLA-B*27:04-bound peptidomes...