Carlos A Baez-Pagan
Overview
Explore the profile of Carlos A Baez-Pagan including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
191
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Recent Articles
1.
Capo-Velez C, Delgado-Velez M, Baez-Pagan C, Lasalde-Dominicci J
Cell Mol Neurobiol
. 2018 Jul;
38(7):1335-1348.
PMID: 30008143
Infection with the human immunodeficiency virus (HIV) remains a threat to global health. Since its discovery, many efforts have been directed at understanding the mechanisms and consequences of infection. Although...
2.
Capo-Velez C, Morales-Vargas B, Garcia-Gonzalez A, Grajales-Reyes J, Delgado-Velez M, Madera B, et al.
Sci Rep
. 2018 Jan;
8(1):1829.
PMID: 29379089
Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an...
3.
Grajales-Reyes J, Garcia-Gonzalez A, Maria-Rios J, Grajales-Reyes G, Delgado-Velez M, Baez-Pagan C, et al.
J Neuromuscul Dis
. 2017 Oct;
4(4):341-347.
PMID: 29036836
Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using running...
4.
Baez-Pagan C, Del Hoyo-Rivera N, Quesada O, Otero-Cruz J, Lasalde-Dominicci J
J Membr Biol
. 2016 Apr;
249(4):539-49.
PMID: 27116687
The nicotinic acetylcholine receptor (nAChR), located in the cell membranes of neurons and muscle cells, mediates the transmission of nerve impulses across cholinergic synapses. In addition, the nAChR is also...
5.
Delgado-Velez M, Baez-Pagan C, Gerena Y, Quesada O, Santiago-Perez L, Capo-Velez C, et al.
Clin Transl Immunology
. 2016 Jan;
4(12):e53.
PMID: 26719799
Antiretroviral therapy partially restores the immune system and markedly increases life expectancy of HIV-infected patients. However, antiretroviral therapy does not restore full health. These patients suffer from poorly understood chronic...
6.
Ramos F, Delgado-Velez M, Ortiz A, Baez-Pagan C, Quesada O, Lasalde-Dominicci J
J Neurovirol
. 2015 Nov;
22(3):327-35.
PMID: 26567012
Despite the recent advances in antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) remains a global health threat. HIV-1 affects the central nervous system by releasing viral proteins that trigger...
7.
Oyola-Cintron J, Caballero-Rivera D, Ballester L, Baez-Pagan C, Martinez H, Velez-Arroyo K, et al.
J Biol Chem
. 2015 Sep;
290(44):26790-800.
PMID: 26354438
Lipid rafts, specialized membrane microdomains in the plasma membrane rich in cholesterol and sphingolipids, are hot spots for a number of important cellular processes. The novel nicotinic acetylcholine receptor (nAChR)...
8.
Biaggi-Labiosa N, Aviles-Pagan E, Caballero-Rivera D, Baez-Pagan C, Lasalde-Dominicci J
Neuropharmacology
. 2015 May;
99:273-84.
PMID: 25957813
The α4β2 neuronal nicotinic acetylcholine receptor (nAChR) plays a crucial role in nicotine addiction. These receptors are known to desensitize and up-regulate after chronic nicotine exposure, but the mechanism remains...
9.
Baez-Pagan C, Delgado-Velez M, Lasalde-Dominicci J
J Neuroimmune Pharmacol
. 2015 Apr;
10(3):468-76.
PMID: 25870122
Inflammatory responses to stimuli are essential body defenses against foreign threats. However, uncontrolled inflammation may result in serious health problems, which can be life-threatening. The α7 nicotinic acetylcholine receptor, a...
10.
Zhu H, Grajales-Reyes G, Alicea-Vazquez V, Grajales-Reyes J, Robinson K, Pytel P, et al.
Exp Neurol
. 2014 Dec;
270:88-94.
PMID: 25448156
The slow-channel congenital myasthenic syndrome (SCS) is an inherited neurodegenerative disease that caused mutations in the acetylcholine receptor (AChR) affecting neuromuscular transmission. Leaky AChRs lead to Ca(2+) overload and degeneration...