Manuel Delgado-Velez
Overview
Explore the profile of Manuel Delgado-Velez including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
176
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Recent Articles
1.
Cunningham C, Dimopoulos Y, Garcia-Quinones I, Milton D, Delgado-Velez M, Cho W, et al.
J Cutan Pathol
. 2025 Jan;
52(4):317-323.
PMID: 39814046
Background: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy with neuroendocrine differentiation. Several molecular pathways have been implicated in MCC development and multiple cell-of-origin candidates have been proposed,...
2.
Roa-Vidal N, Rodriguez-Aponte A, Lasalde-Dominicci J, Capo-Velez C, Delgado-Velez M
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958716
Macrophages serve as vital defenders, protecting the body by exhibiting remarkable cellular adaptability in response to invading pathogens and various stimuli. These cells express nicotinic acetylcholine receptors, with the α7-nAChR...
3.
Akamine P, Gonzalez-Feliciano J, Almodovar R, Morell G, Rivera J, Capo-Velez C, et al.
Vaccines (Basel)
. 2023 May;
11(5).
PMID: 37243079
We have developed a pipeline to express, purify, and characterize HIV envelope protein (Env) gp145 from Chinese hamster ovary cells, to accelerate the production of a promising vaccine candidate. First...
4.
Delgado-Velez M, Quesada O, Villalobos-Santos J, Maldonado-Hernandez R, Asmar-Rovira G, Stevens R, et al.
Molecules
. 2021 Oct;
26(19).
PMID: 34641297
Since their discovery, nicotinic acetylcholine receptors (nAChRs) have been extensively studied to understand their function, as well as the consequence of alterations leading to disease states. Importantly, these receptors represent...
5.
Gonzalez-Feliciano J, Capo-Velez C, Akamine P, Delgado-Velez M, Almodovar R, Rivera J, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2021 Feb;
1167:122562.
PMID: 33571843
A reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the quantitative determination of recombinant HIV-1 gp145 produced in CHO-K1 cells, as measured directly from culture supernatants. Samples...
6.
Gonzalez-Feliciano J, Akamine P, Capo-Velez C, Delgado-Velez M, Dussupt V, Krebs S, et al.
PLoS One
. 2020 Jun;
15(6):e0231679.
PMID: 32559193
The envelope glycoprotein (Env) of the human immunodeficiency virus (HIV), has been the primary target for the development of a protective vaccine against infection. The extensive N-linked glycosylation on Env...
7.
Capo-Velez C, Delgado-Velez M, Baez-Pagan C, Lasalde-Dominicci J
Cell Mol Neurobiol
. 2018 Jul;
38(7):1335-1348.
PMID: 30008143
Infection with the human immunodeficiency virus (HIV) remains a threat to global health. Since its discovery, many efforts have been directed at understanding the mechanisms and consequences of infection. Although...
8.
Delgado-Velez M, Lasalde-Dominicci J
Int J Mol Sci
. 2018 May;
19(5).
PMID: 29772664
Macrophages are phagocytic immune cells that protect the body from foreign invaders and actively support the immune response by releasing anti- and proinflammatory cytokines. A seminal finding revolutionized the way...
9.
Capo-Velez C, Morales-Vargas B, Garcia-Gonzalez A, Grajales-Reyes J, Delgado-Velez M, Madera B, et al.
Sci Rep
. 2018 Jan;
8(1):1829.
PMID: 29379089
Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an...
10.
Grajales-Reyes J, Garcia-Gonzalez A, Maria-Rios J, Grajales-Reyes G, Delgado-Velez M, Baez-Pagan C, et al.
J Neuromuscul Dis
. 2017 Oct;
4(4):341-347.
PMID: 29036836
Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using running...