Carl Sikkema
Overview
Explore the profile of Carl Sikkema including associated specialties, affiliations and a list of published articles.
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9
Citations
156
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Recent Articles
1.
Edwards M, Nguyen H, Dodson A, Herbertson A, Wolden-Hanson T, Wietecha T, et al.
bioRxiv
. 2024 Jun;
PMID: 38854021
Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet-induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently...
2.
Hendrickson R, Raskind M, Millard S, Sikkema C, Terry G, Pagulayan K, et al.
Neurobiol Stress
. 2018 Jun;
8:103-111.
PMID: 29888305
Background: Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE)...
3.
Wang L, Raskind M, Wilkinson C, Shofer J, Sikkema C, Szot P, et al.
Int J Geriatr Psychiatry
. 2018 Feb;
33(5):763-768.
PMID: 29446123
Objective: This study evaluated the effects of Alzheimer disease (AD) on the relationship between the brain noradrenergic system and hypothalamic pituitary adrenocortical axis (HPA). Specifically, relationships between cerebrospinal fluid (CSF)...
4.
Kow R, Sikkema C, Wheeler J, Wilkinson C, Kraemer B
Biol Psychiatry
. 2017 Jul;
83(5):438-446.
PMID: 28751068
Background: The microtubule-associated protein tau accumulates into toxic aggregates in multiple neurodegenerative diseases. We found previously that loss of D-family dopamine receptors ameliorated tauopathy in multiple models including a Caenorhabditis...
5.
Ben-Hamo M, Larson T, Duge L, Sikkema C, Wilkinson C, de la Iglesia H, et al.
eNeuro
. 2017 Jan;
3(6).
PMID: 28090585
In mammals, a master circadian clock within the suprachiasmatic nucleus (SCN) of the hypothalamus maintains the phase coherence among a wide array of behavioral and physiological circadian rhythms. Affective disorders...
6.
Szot P, Franklin A, Miguelez C, Wang Y, Vidaurrazaga I, Ugedo L, et al.
Neuropharmacology
. 2015 Sep;
101:76-86.
PMID: 26362360
Depression is a common co-morbid condition most often observed in subjects with mild cognitive impairment (MCI) and during the early stages of Alzheimer's disease (AD). Dysfunction of the central noradrenergic...
7.
Wang L, Murphy R, Hanscom B, Li G, Millard S, Petrie E, et al.
Neurobiol Aging
. 2013 May;
34(10):2287-92.
PMID: 23639207
Adequate central nervous system noradrenergic activity enhances cognition, but excessive noradrenergic activity may have adverse effects on cognition. Previous studies have also demonstrated that noradrenergic activity is higher in older...
8.
Szot P, Franklin A, Sikkema C, Wilkinson C, Raskind M
Front Pharmacol
. 2012 Nov;
3:184.
PMID: 23129999
Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson's disease (PD) and the LC exhibits neuropathological changes early in the disease process. It has been suggested that...
9.
Falowski S, Sharan A, Reyes B, Sikkema C, Szot P, Van Bockstaele E
Neurosurgery
. 2011 May;
69(6):1281-90.
PMID: 21566538
Background: Recent interest has demonstrated the nucleus accumbens (NAcc) as a potential target for the treatment of depression with deep brain stimulation (DBS). Objective: To demonstrate that DBS of the...