Carl P Decicco
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Explore the profile of Carl P Decicco including associated specialties, affiliations and a list of published articles.
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56
Citations
339
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Recent Articles
1.
Corte J, Fang T, Osuna H, Pinto D, Rossi K, Myers Jr J, et al.
J Med Chem
. 2017 Jan;
60(3):1060-1075.
PMID: 28085275
A novel series of macrocyclic FXIa inhibitors was designed based on our lead acyclic phenyl imidazole chemotype. Our initial macrocycles, which were double-digit nanomolar FXIa inhibitors, were further optimized with...
2.
Gillman K, Starrett Jr J, Parker M, Xie K, Bronson J, Marcin L, et al.
ACS Med Chem Lett
. 2014 Jun;
1(3):120-4.
PMID: 24900185
During the course of our research efforts to develop a potent and selective γ-secretase inhibitor for the treatment of Alzheimer's disease, we investigated a series of carboxamide-substituted sulfonamides. Optimization based...
3.
Cherney R, Mo R, Yang M, Xiao Z, Zhao Q, Mandlekar S, et al.
Bioorg Med Chem Lett
. 2014 Mar;
24(7):1843-5.
PMID: 24613378
We describe novel alkylsulfones as potent CCR2 antagonists with reduced hERG channel activity and improved pharmacokinetics over our previously described antagonists. Several of these new alkylsulfones have a profile that...
4.
Cherney R, Mo R, Meyer D, Pechulis A, Guaciaro M, Lo Y, et al.
Bioorg Med Chem Lett
. 2012 Sep;
22(19):6181-4.
PMID: 22939233
We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CCR2 antagonists. 7-Trifluoromethylbenzimidazoles displayed potent binding and functional antagonism of CCR2 while...
5.
Carter P, Brown G, King S, Voss M, Tebben A, Cherney R, et al.
Bioorg Med Chem Lett
. 2012 Apr;
22(9):3311-6.
PMID: 22475558
We describe an isostere-driven approach to improve upon a previously-described series of capped dipeptide antagonists of CC Chemokine Receptor 2 (CCR2). Modification of the substitution around the isostere was combined...
6.
Thompson L, Shi J, Decicco C, Tebben A, Olson R, Boy K, et al.
Bioorg Med Chem Lett
. 2011 Oct;
21(22):6909-15.
PMID: 21974952
The synthesis, evaluation, and structure-activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal...
7.
Cherney R, Mo R, Meyer D, Voss M, Yang M, Santella 3rd J, et al.
Bioorg Med Chem Lett
. 2010 Mar;
20(8):2425-30.
PMID: 20346664
We describe the design, synthesis, and evaluation, of gamma-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2 antagonists. The lactam-containing trisubstituted cyclohexanes proved to be more...
8.
Cherney R, Mo R, Meyer D, Voss M, Lo Y, Yang G, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(13):3418-22.
PMID: 19481449
Potent sulfone-containing di- and trisubstituted cyclohexanes were synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the trisubstituted derivative 54, which exhibited excellent binding (CCR2 IC(50)=1.3nM)...
9.
Cherney R, Brogan J, Mo R, Lo Y, Yang G, Miller P, et al.
Bioorg Med Chem Lett
. 2009 Jan;
19(3):597-601.
PMID: 19131247
A series of trisubstituted cyclohexanes was designed, synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. This led to the identification of two distinct substitution patterns about the cyclohexane...
10.
Cherney R, Nelson D, Lo Y, Yang G, Scherle P, Jezak H, et al.
Bioorg Med Chem Lett
. 2008 Aug;
18(18):5063-5.
PMID: 18722120
A series of cis-3,4-disubstituted piperidines was synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. Compound 24 emerged with an attractive profile, possessing excellent binding (CCR2 IC(50)=3.4 nM) and...