Carl J Johnston
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Explore the profile of Carl J Johnston including associated specialties, affiliations and a list of published articles.
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55
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917
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Recent Articles
11.
Groves A, Paris N, Hernady E, Johnston C, Aljitawi O, Lee Y, et al.
Int J Radiat Oncol Biol Phys
. 2022 Nov;
115(4):972-982.
PMID: 36400304
Purpose: Pelvic radiation therapy (RT) can cause debilitating bladder toxicities but few clinical interventions exist to prevent injury or alleviate symptoms. From a large genome-wide association study in patients with...
12.
Uchida H, Ingalls M, Maruyama E, Johnston C, Hernady E, Faustoferri R, et al.
Dis Model Mech
. 2022 Oct;
15(11).
PMID: 36263624
Many patients treated for head and neck cancers experience salivary gland hypofunction due to radiation damage. Understanding the mechanisms of cellular damage induced by radiation treatment is important in order...
13.
Uccello T, Lesch M, Ullman N, Kintzel S, Gradzewicz L, Velagaleti T, et al.
Int J Radiat Oncol Biol Phys
. 2022 Oct;
115(3):733-745.
PMID: 36202180
Purpose: Many solid tumors present with perineural invasion (PNI), and innervation correlates with worsened prognosis. The effects that commonly administered therapies such as radiation therapy (RT) have on PNI status...
14.
Ye J, Mills B, Qin S, Garrett-Larsen J, Murphy J, Uccello T, et al.
J Immunother Cancer
. 2022 Jul;
10(7).
PMID: 35851308
Background: Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen...
15.
OConnor T, Kallenbach J, Orciuoli H, Paris N, Bachman J, Johnston C, et al.
Skelet Muscle
. 2022 Apr;
12(1):8.
PMID: 35414122
Background: Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlying mechanisms have yet to be fully elucidated. We hypothesized that...
16.
Uccello T, Kintzel S, Mills B, Murphy J, Garrett-Larsen J, Battaglia N, et al.
Adv Radiat Oncol
. 2022 Jan;
7(2):100867.
PMID: 35036637
Purpose: Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal tumors for radiation therapy (RT) without inducing systemic toxicity remains a barrier....
17.
House E, Kim S, Johnston C, Groves A, Hernady E, Misra R, et al.
Toxics
. 2021 Dec;
9(12).
PMID: 34941793
Diacetyl (DA) is a highly reactive alpha diketone associated with flavoring-related lung disease. In rodents, acute DA vapor exposure can initiate an airway-centric, inflammatory response. However, this immune response has...
18.
Croft D, Burton D, Nagel D, Bhattacharya S, Falsey A, Georas S, et al.
Sci Rep
. 2021 Oct;
11(1):19436.
PMID: 34593881
Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hypothesized...
19.
Whitelaw B, Tanny S, Johnston C, Majewska A, OBanion M, Marples B
Int J Radiat Oncol Biol Phys
. 2021 Jul;
111(4):1066-1071.
PMID: 34314813
Purpose: Whole brain radiation therapy (WBRT) is an important treatment for patients with multiple brain metastases, but can also cause cognitive deterioration. Microglia, the resident immune cells of the brain,...
20.
Wang J, Kim S, House E, Olson H, Johnston C, Chalupa D, et al.
Arch Toxicol
. 2021 May;
95(7):2469-2483.
PMID: 34031698
Bronchiolitis obliterans (BO) is a devastating lung disease seen commonly after lung transplant, following severe respiratory tract infection or chemical inhalation exposure. Diacetyl (DA; 2,3-butanedione) is a highly reactive alpha-diketone...